| 肿瘤淋巴管生成的研究进展 |
| |
| 引用本文： | 严超,朱正纲. 肿瘤淋巴管生成的研究进展[J]. 中国癌症杂志, 2003, 13(5): 475-479 |
| |
| 作者姓名： | 严超 朱正纲 |
| |
| 作者单位： | 上海第二医科大学附属瑞金医院外科,上海消化外科研究所,上海,200025 |
| |
| 摘 要： | 淋巴管对实体瘤的转移起着重要作用，目前研究表明，淋巴管生成因子（VEGF-C和VEGF-D）可通过激活其位于淋巴管内皮细胞上的受体（VEGFR-3）促进肿瘤内淋巴管生成，进而增加淋巴结转移率。同时，阻断VEGFR-3信号通道可抑制肿瘤淋巴管生成及淋巴结转移。因此，抗肿瘤淋巴管生成有望成为肿瘤转移抑制治疗的一条新途径。
|
| 关 键 词： | 肿瘤 淋巴管生成 血管内皮生长因子 VEGF 淋巴结转移 |
| 文章编号： | 1007-3639(2003)05-0475-05 |
| 修稿时间： | 2002-08-05 |
Progress in the research of tumor lymphangiogenesis |
| |
| YAN Chao,ZHU Zheng gang. Progress in the research of tumor lymphangiogenesis[J]. China Oncology, 2003, 13(5): 475-479 |
| |
| Authors: | YAN Chao ZHU Zheng gang |
| |
| Abstract: | Lymphatic vessels are important for the spread of solid tumors, and recent researches indicated that lymphangiogenic factors(VEGF C and VEGF D)could stimulate lymphangiogenesis in tumors by activating their receptors on the lymphatic endothelial cells, then enhance the incidence of lymph node metastasis. In addition, inhibition of VEGFR 3 signaling could suppress tumor lymphangiogenesis and metastasis to lymph nodes, thus, inhibition of lymphangiogenesis can be expected to be a new method of blocking tumor metastasis. |
| |
| Keywords: | tumor lymphangiogenesis vascular endothelial growth factor lymph node metastasis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
