Superparamagnetic iron oxide nanoparticles for in vivo molecular and cellular imaging |
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| Authors: | Sophie Laurent Fatemeh Atyabi Amir Ata Saei Morteza Mahmoudi |
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| Affiliation: | 1. Department of General, Organic, and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, Mons, Belgium;2. CMMI – Center for Microscopy and Molecular Imaging, Gosselies, Belgium;3. Nanotechnology Research Center and Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;4. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden;5. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA;6. Cardiovascular Institute, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA |
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| Abstract: | In the last decade, the biomedical applications of nanoparticles (NPs) (e.g. cell tracking, biosensing, magnetic resonance imaging (MRI), targeted drug delivery, and tissue engineering) have been increasingly developed. Among the various NP types, superparamagnetic iron oxide NPs (SPIONs) have attracted considerable attention for early detection of diseases due to their specific physicochemical properties and their molecular imaging capabilities. A comprehensive review is presented on the recent advances in the development of in vitro and in vivo SPION applications for molecular imaging, along with opportunities and challenges. Copyright © 2015 John Wiley & Sons, Ltd. |
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| Keywords: | cellular imaging iron oxide molecular imaging MRI SPIONs superparamagnetic nanoparticles |
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