Flat and depressed colorectal tumours in a southern Swedish population: a prospective chromoendoscopic and histopathological study |
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Authors: | Tsuda S Veress B Tóth E Fork F-T |
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Institution: | Endoscopy Unit, Department of Radiology, University Hospital Malm?, Sweden. |
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Abstract: | BACKGROUND: Flat and depressed colorectal tumours are common in Japan but are very rare or non-existent in Western countries. AIMS: To study the occurrence of flat colorectal tumours in a southern Swedish population. METHODS: In this prospective study, 371 consecutive European patients were examined by high resolution video colonoscopy combined with chromoendoscopy. The nature of the lesions was determined by histopathological examination. RESULTS: A total of 973 tumours were found; 907 (93.2%) were protruding and 66 (6.8%) were flat or depressed. Of the flat/depressed tumours, five (7.7%) were early adenocarcinomas infiltrating the submucosa. Eleven carcinomas (1.2%) were found among protruding tumours. High grade dysplasia was observed in 18% (n=11) of flat/depressed adenomas in contrast with 7.3% (n=65) of protruding adenomas, and occurred in smaller flat/depressed tumours compared with protruding ones (mean diameter 8 mm v 23 mm, respectively). Furthermore, high grade dysplasia was significantly more common in flat elevated tumours with central depression or in depressed adenomas (35.7%; 5/14) than in flat elevated adenomas (12.8%; 6/47). CONCLUSION: Flat and depressed tumours exist in a Western population. Future studies should address whether or not chromoendoscopy with video colonoscopy is necessary in the search for flat colorectal neoplasms. |
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