| 三种血清标志物在肺癌中的应用价值 |
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| 引用本文： | 凌存保,郭广宏,向荣,田亚平.三种血清标志物在肺癌中的应用价值[J].标记免疫分析与临床,2010,17(4):209-211. |
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| 作者姓名： | 凌存保 郭广宏 向荣 田亚平 |
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| 作者单位： | 中国人民解放军总医院生化科,北京,100853;南开大学医学院,天津,300071;中国人民解放军总医院生化科,北京,100853;南开大学医学院,天津,300071 |
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| 基金项目： | 国家科技部重大专项，国家科技支撑计划 |
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| 摘 要： | 为分析血清CEA、CYFRA21-1及NSE在辅助鉴别诊断肺癌及肺部良性疾病临床应用价值,回顾了我院2009年1月至10月的287例肺部疾病患者以及60名健康体检者血清CEA、CYFRA21-1及NSE数据。肺癌分为三组即肺腺癌、肺鳞癌和小细胞肺癌。良性疾病组包括肺炎和肺结核等。对所测结果用统计软件SPSS16.0进行统计。结果表明：肺癌组的三项血清标志物水平明显高于良性疾病组和健康对照组（P〈0.01）。CEA在肺腺癌患者血清中浓度明显高于其它组（P〈0.01）。CYFRA21-1在肺鳞癌患者血清中浓度明显高于其它肺癌类型及良性和健康对照组（P〈0.01）,且对肺鳞癌有较高的灵敏度,而NSE在小细胞肺癌患者中的浓度及阳性率与其余组有显著性差异（P〈0.01）。CEA联合CYFRA21-1可以提高对肺腺癌和肺鳞癌的敏感度。CEA联合NSE可提高对小细胞肺癌的敏感度。三项联合检测对各型的肺癌都有较高敏感度。
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| 关 键 词： | 肺癌 CEA CYFRA21-1 NSE 血清 |
Clinical Significance of Three Serum Tumor Markers in Lung Cancer |
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| LING Cun-bao,GUO Guang-hong,XIANG Rong,TIAN Ya-ping.Clinical Significance of Three Serum Tumor Markers in Lung Cancer[J].Labeled Immunoassays and Clinical Medicine,2010,17(4):209-211. |
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| Authors: | LING Cun-bao GUO Guang-hong XIANG Rong TIAN Ya-ping |
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| Institution: | LING Cun-bao,GUO Guang-hong,XIANG Rong,TIAN Ya-ping(Department of Clinical Biochemistry,Chinese PLA General Hospital,Beijing 100853,China) |
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| Abstract: | To investigate the clinical significance of serum CEA,CYFRA21-1 and NSE in lung cancer,287 patients and 60 normal controls in our hospital from January to October in 2009 has been studied retrospectively.The results showed that the serum levels of CEA,NSE and CYFRA2 1-1 in lung cancer patients were significantly higher than those in normal controls(P<0.01).The serum CEA and positive rate in lung adenocarcinoma were higher than that of other lung cancer groups(P<0.01).The serum CYFRA21-1 and positive rate in... |
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| Keywords: | CEA CYFRA21-1 NSE |
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