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| 江浙沪地区HLA-DQB1基因对重症肌无力的遗传易感性研究 | |
| 引用本文： | 杜可明,张可雄,陈秀珍,左及,夏培莉,吕传真,郝中顺.江浙沪地区HLA-DQB1基因对重症肌无力的遗传易感性研究[J].中国免疫学杂志,2000,16(6):297-299. |
| 作者姓名： | 杜可明 张可雄 陈秀珍 左及 夏培莉 吕传真 郝中顺 |
| 作者单位： | 1. 山东省泰山医学院医学遗传学教研室,泰安,271000 2. 上海医科大学医学遗传学教研室,上海,200032 3. 上海医科大学华山医院神经内科,上海,200040 |
| 基金项目： | 国家青年自然科学基金资助!(No.39500049) |
| 摘 要： | 探讨中国汉人ＭＧ易感性与ＨＬＡ－ＤＱＢ１基因多态性的相关。方法：运用ＰＣＲ－ＲＦＬＰ法进行ＨＬＡ－ＤＱＢ１基因分型。结果：ＭＧ病例组与对照组比较都有ＤＱＢ＊０３０３频率的明显增高,ＤＱＢ＊０６０１和ＤＱＢ１＊０．６０２频率的明显降低,差异都有显著性。结论：ＤＱＢ１＊０３０３参与中国汉人ＭＧ的易感性,而ＤＱＢ１＊０６０１和ＤＱＢ１＊０６０２是保护基因。 |
| 关 键 词： | 重症肌无力 HLA－DQB1 基因多态性 遗传易感性 |
Study on HLA-DQB1 polymorphism to myasthenia gravis susceptibility in Chinese Jiangzhehu areas |
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| DU KeMing,ZHANG KeXiong,CHEN XiuZhen et al.Study on HLA-DQB1 polymorphism to myasthenia gravis susceptibility in Chinese Jiangzhehu areas[J].Chinese Journal of Immunology,2000,16(6):297-299. | |
| Authors: | DU KeMing ZHANG KeXiong CHEN XiuZhen |
| Institution: | DU KeMing,ZHANG KeXiong,CHEN XiuZhen et al.The Department of Medical Genetics of Shanghai Medical University,Shanghai 200032 |
| Abstract: | Objective:Analyze the association HLADQB1 gene polymorphism and MG susceptibility in Chinese Hans. Methods:HLADQB1 were genetyped using PCRRFLP. Results:Compared the frequency of HLADQB1 alleles between MG patients (included subgroups) and the healthy controls. The frequency of DQB1*0303 was significantly increased,and the frequency of DQB1*0601 and DQB1*0602 was significantly decreased. The differences were statisticaly. Conclusion:DQB1*0303 was susceptible to MG in Chinese Hans. DQB1*0601and DQB1*0602 were protective genes. |
| Keywords: | Myasthenia gravis HLA-DQB1 Gene polymorphism Genetic susceptibility |
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