缺血性脑卒中CT灌注成像与预后的相关性临床研究

目的探讨缺血性脑卒中患者的CT灌注成像与临床预后的相关性。方法回顾性分析2017年1月~2018年12月我院收治的102例缺血性脑卒中患者的临床资料。患者均接收CT灌注成像检查并使用perfusion CT/VA10B软件进行数据处理。比较患者梗死区和缺血半暗带区的相对脑血流量(rCBF)、相对脑血容量(rCBV)、相对平均通过时间(rMTT)、相对达峰时间(rTTP),分析其与缺血性脑卒中患者的缺血脑组织可恢复比率(PRR)的关系,以及与美国国立卫生研究院卒中量表(NIHSS)评分的相关性。结果缺血性脑卒中患者梗死区rCBF、rCBV低于缺血半暗带(P<0.05),rMTT、rTTP高于缺血半暗带(P<0.05);缺血性脑卒中患者的PRR与NIHSS具有显著的正相关性(r=0.558、0.611,P<0.05)。结论缺血性脑卒中患者梗死区和缺血半暗带的血液动力学情况具有显著差异,且缺血脑组织的可恢复情况与疾病预后有明显的相关性,CT灌注成像可为临床治疗和预后评估提供可靠的影像学依据。

Clinical Study on Correlation Between CT Perfusion Imaging and Prognosis in Ischemic Stroke

Objective To explore the correlation between CT perfusion imaging findings and clinical prognosis in patients with ischemic stroke. Methods The clinical data of 102 patients with ischemic stroke admitted to our hospital from January 2017 to December 2018 were retrospectively analyzed. Patients were given CT perfusion imaging examination, and analyzed by perfusion CT/VA10B software for data processing. The relative cerebral blood flow(rCBF), relative cerebral blood volume(rCBV), relative mean transit time(rMTT) and relative time-to-peak(rTTP) were compared between the infarct regimen and ischemic penumbra, and the correlation between the recuperation ratio(PRR) of ischemic brain tissues and National Institutes of Health Stroke Scale(NIHSS) score was analyzed among patients with ischemic stroke. Results The rCBF and rCBV in infarct region of patients with ischemic stroke were lower than those in ischemic penumbra(P<0.05) while the rMTT and rTTP were higher than those in ischemic penumbra(P<0.05). The PRR of patients with ischemic stroke was significantly positively correlated with NIHSS(r=0.558, 0.611, P<0.05). Conclusion The hemodynamics of infarcted region and ischemic penumbra in patients with ischemic stroke are significantly different, and the potential recuperation of ischemic brain tissues is significantly correlated with disease prognosis. CT perfusion imaging can provide a reliable imaging basis for clinical treatment and prognostic assessment.