| 蛇床子素抑制血栓形成及其作用机制研究 |
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| 引用本文： | 陈蓉,;谢梅林.蛇床子素抑制血栓形成及其作用机制研究[J].中国航天工业医药,2008(10):50-52. |
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| 作者姓名： | 陈蓉 ;谢梅林 |
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| 作者单位： | [1]苏州大学附属第一医院药剂科,215006; [2]苏州大学医学院药理学教研室,215006; |
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| 摘 要： | 目的研究蛇床子素抑制血栓形成及其可能的作用机制。方法利用大鼠静脉血栓形成模型和动-静脉旁路血栓形成模型测定给予蛇床子素10mg／kg、20mg／kg、40mg／kg后血栓湿重和干重，同时在动-静脉旁路血栓形成模型中测定大鼠血清NO含量，血浆TXB2和6-keto—PGF1α的含量。结果蛇床了素20mg／kg、40mg／kg组可以明显抑制大鼠静脉血栓形成，减轻血栓湿重和于重；蛇床子素10mg／kg、20mg／kg、40mg／kg组可以明显抑制大鼠动-静脉旁路血栓形成，减轻血栓湿重和干重，同时增加血清中NO的含量，降低血浆中TXB2的含量和增加血浆中6-keto—PGF1α的含量。结论蛇床子素可明显抑制大鼠血栓形成．其作用机制可能与增加血清中NO的含量，降低血浆中TXB2的含量和TXB2/6-keto—PGF1α的比值有关。
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| 关 键 词： | 蛇床子素 血栓形成一氧化氮 血栓烷B2 6-酮-前列腺素F1α |
Effects of osthole on antithrombosis and its mechanisms |
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| Institution: | Chen Rong, Xie Meilin(The First Hospital Affiliated to Soochow University, Suzhou 215006) |
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| Abstract: | Objective To study of osthole on antithrombosis and its mechanisms. Methods The rat models of venous thrombosis and artery-vein bypass thrombosis were used to measure the thrombus weight, and the levels of NO in serum, TXB2 and 6-keto-PGF1α in plasma were measured in the rat model of artery-vein bypass thrombosis. Results Rat venous thrombosis in osthole groups was inhibited and thrombus weight was decreased. After treated with osthole 10-40mg/kg, artery-vein bypass thrombus weight, plasma TXB2 level and the ratio of TXB2/6-keto-PGF1α were reduced, while serum NO level was increased. Conclusion Osthole exerted remarkable effects against the thrombosis, and its mechanisms might be associated with increase of NO level, reduction of TXB2 level and TXB2/6-keto-PGF1α ratio. |
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| Keywords: | Osthole Thrombosis NO TXB2 6-keto-PGF1α |
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