药物性肝损害36例临床分析

目的提高对药物性肝损害诊断的准确性。方法对36例药物性肝损害（DILI）患者的临床资料进行回顾性分析。结果在药物性肝损害患者中，中药9例（25％），居首位，其次为抗生素7例（19.4％）和抗结核药物6例（16．7％）。临床主要表现为皮肤巩膜黄染（55．6％）、乏力（47.2％）、纳差（44．4％）；其中肝细胞损伤型22．2％，胆汁淤积型66．7％，混合型11．1％．结论药物性肝损害是临床常见病，应重视中药的肝毒性，提高对药物性肝损害的识别，尤其应重视胆汁淤积型肝病的鉴别诊断。

Preliminary clinical study on drug induced liver injury in 36 patients

Objective To improve the diagnosis on drug induced liver injury （DILI）. Methods The retrospective study on the clinical data of 36 cases of DILI in the last five years of our hospital. Results A variety of drugs, including traditional chinese medieine （25% of our total cases）, antimierobial agents （19.4%） and tubereulostatic agents （16.7%）. The main clinical manifestations of it were jaundice （55.6%）, fatigue （47.2%）, and nausea （44.4%）. With clinical manifestations 22.2% of patients were classified as hepatocelluar type, 66.7% as cholestatic type and 11.1% as mixed type. Conclusion The drugs that can cause liver injury should be used carefully.