Inhibition of Pentagastrin-Stimulated Gastric Acid Secretion by Pantoprazole and Omeprazole in Healthy Adults |
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Authors: | Vijaya S Pratha MD Daniel L Hogan PhD James R Lane PharmD Paul J Williams PharmD Michael S Burton Richard B Lynn MD Robyn G Karlstadt MD |
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Institution: | (1) Clinical Applications Laboratories, Inc., San Diego, California;(2) Wyeth Pharmaceuticals, Collegeville, Pennsylvania, USA;(3) CAL, Inc., 3330 Third Avenue, Suite 303, San Diego, California 92103, USA |
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Abstract: | Our objective was to compare the onset and duration of a single dose of pantoprazole or omeprazole on maximally stimulated
gastric acid secretion. This double-blind, randomized, placebo-controlled study involved 36 healthy adults and utilized continuous
pentagastrin infusion to stimulate acid secretion after administration of pantoprazole, 40 mg, omeprazole, 20 mg, or placebo.
Gastric aspirates were collected over 24 hr and analyzed for volume, pH, and hydrogen ion concentration, and gastric acid
outputs (GAO) were calculated. Comparison between GAO and intragastric pH was performed. Pantoprazole resulted in significantly
greater inhibition of GAO than omeprazole. Mean cumulative 24-hr GAO was 164 ± 130 mEq for pantoprazole versus 283 ± 159 mEq
for omeprazole (P = 0.031). Pantoprazole patients reached and maintained GAO levels below the 10-mEq/hr threshold at 5.7 hr, whereas omeprazole
patients never reached this threshold. We conclude that pantoprazole significantly suppressed gastric acid secretion compared
to omeprazole. Comparisons between pH and GAO showed that GAO was a more appropriate measure of gastric acid secretion than
intragastric pH.
This work received financial support from Wyeth Pharmaceuticals. |
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Keywords: | gastric acid output maximal acid output pantoprazole omeprazole proton pump inhibitors |
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