| 加减地黄饮子对局灶性脑缺血大鼠神经元保护作用的实验研究 |
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| 引用本文： | 段新芬,李文英,谢宁.加减地黄饮子对局灶性脑缺血大鼠神经元保护作用的实验研究[J].山东中医药大学学报,2009,33(4). |
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| 作者姓名： | 段新芬 李文英 谢宁 |
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| 作者单位： | 段新芬,DUAN Xinf-en(南方医科大学中医药学院,广东,广州,510515);李文英,谢宁,LI Wen-ying,XIE Ning(黑龙江中医药大学,黑龙江,哈尔滨,150040) |
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| 基金项目： | 黑龙江省自然科学基金 |
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| 摘 要： | 目的:观察加减地黄饮子对局灶性脑缺血大鼠神经元的保护作用及其可能作用机制。方法:采用栓线法制作大鼠局灶性脑缺血损伤模型(MCAO)。120只Wistar大鼠随机分成6组:空白组,假损伤组,模型组,中药高剂量组,中药低剂量组,阿司匹林对照组,每组20只。连续灌胃7d后,进行手术操作。测定大鼠大脑皮层组织Na+-K+-ATP酶活性、Ca2+-ATP酶活性、SOD活性和MDA含量。结果:加减地黄饮子低剂量、高剂量组均能提高脑缺血大鼠大脑皮层组织的Na+-K+-ATP酶、Ca2+-ATP酶活性及SOD活性,降低MDA含量。结论:加减地黄饮子可对局灶性脑缺血大鼠脑组织神经元起保护作用,其脑保护作用机制可能与其调节Na+-K+-ATP酶和Ca2+-ATP酶活性、SOD活性和降低MDA含量有关。
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| 关 键 词： | 加减地黄饮子 局灶性脑缺血 Na+-K+-ATPase Ca2+-ATPase 氧化应激 大鼠 |
Protective effect of modified Dihuang Yinzi on the nerve cell in rats with focal cerebral ischemia |
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| DUAN Xin-fen,LI Wen-ying,XIE Ning.Protective effect of modified Dihuang Yinzi on the nerve cell in rats with focal cerebral ischemia[J].Journal of Shandong University of Traditional Chinese Medicine,2009,33(4). |
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| Authors: | DUAN Xin-fen LI Wen-ying XIE Ning |
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| Institution: | 21.College of Traditional Chinese Medicine;Southern Medical University;Guangzhou 510515;China;2.Heilongjiang University of Traditional Chinese Medicine;Haerbin 150040;China |
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| Abstract: | Objective:To observe the protective effect and the mechanism of modified Dihuang Yinz(iMDY) on nerve cell in rats with focal cerebral ischemia.Methods:120 Wistar rats were divided into 6 groups randomly:normal group,model group,sham operated group,low dose of TCM group,high dose of TCM group and Acenterine group.Use the middle cerebral artery occlusion methods to make focal cerebral ischemia model rats after intragastric administra-tion for 7 days.To observe the activity of Na+-K+-ATPase,Ca2+-ATPase,SOD and... |
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| Keywords: | Na+-K+-ATPase Ca2+-ATPase modified Dihuang Yinzi focal cerebral ischemia Na+-K+-ATPase Ca2+-ATPase oxidative stress rat |
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