| ATP－氯化镁对脑缺血再灌流损伤后胞浆内Na~＋，K~＋，Ca~（2＋），Mg~（2＋）及SOD的影响 |
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| 引用本文： | 郑文淑,玄汉石,王延国,赵春植,任光旭,李永财.ATP－氯化镁对脑缺血再灌流损伤后胞浆内Na~＋，K~＋，Ca~（2＋），Mg~（2＋）及SOD的影响[J].延边医学院学报,1994(3). |
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| 作者姓名： | 郑文淑 玄汉石 王延国 赵春植 任光旭 李永财 |
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| 作者单位： | 延边医学院附属医院神经外科 |
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| 摘 要： | 采用四条血管阻断方法制成家兔急性全脑缺血再灌流模型，观察家兔脑组织胞浆内ＳＯＤ及Ｎａ＋，Ｋ＋，Ｃａ（２＋），Ｍｇ（２＋）含量变化，结果发现家兔脑组织单纯缺血时ＳＯＤ活力明显下降（与正常对照组相比Ｐ＜０．０１），缺血再灌流后ＳＯＤ活力又较单纯缺血组进一步下降（Ｐ＜０．０１），Ｎａ＋，Ｃａ（２＋）在单纯缺血时含量增高（与正常对照组相比Ｐ＜０．０１），而Ｋ＋，Ｍｇ（２＋）则减少（Ｐ＜０．０１）；缺血再灌流后Ｎａ，Ｃａ（２＋）含量较单纯缺血组进一步增高（Ｐ＜０．０１），Ｋ＋，Ｍｇ（２＋）减少（Ｐ＜０．０１）．应用ＡＴＰ－氯化镁治疗后，上述指标与正常对照组相比无显著差异。
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| 关 键 词： | 脑缺血 腺苷三磷酸 超氧化物歧化酶类 |
Affection of ATP-magnesium chrolide to Na￣+,K￣+,Ca￣(2+),Mg￣(2+) ions and superoxide dismutase in cytosol of rabbit' s brain after forebrain ischemia-reperfusion lesion |
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| Zheng Wenshu,Xuan Hanshi,Wang Yanguo,Zhao Chunzhi,Ren Guangxu,Li Yongcai.Affection of ATP-magnesium chrolide to Na￣+,K￣+,Ca￣(2+),Mg￣(2+) ions and superoxide dismutase in cytosol of rabbit' s brain after forebrain ischemia-reperfusion lesion[J].Journal of Medical Science Yanbian University,1994(3). |
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| Authors: | Zheng Wenshu Xuan Hanshi Wang Yanguo Zhao Chunzhi Ren Guangxu Li Yongcai |
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| Abstract: | The model of forebrain ischeinia and reperfusion in rabbits was made by four vessls occlusion. The amounts of superoxide dimutase(SOD)and Na ,K , Ca(2 ),Ma(2 )ions in the cytosol of brain tissue were measured, The levels of SOD were decreased during the simple ischemia and the SOD activities were further reduced after reperfusion. The Na , Ca(2 ) ions were increased and K , Mg(2 ) ions were decreased during the simple ischemia, but the Na ,Ca ions were decreased during the simple ischemia, but the Na ,Ca(2 ) ions were further increased and K , Mg(2 ) ions were further decreased after reperfusion. The above metioned changes in the ATP-magnesium chloride administation group were no different from normal control group. |
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| Keywords: | cerebral ischemia adenosine triphosphate superoxide dismutase |
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