Inactivating and non-inactivating potassium currents in isolated inner hair cells from guinea pig cochlea |
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Authors: | Kimitsuki Takashi Ohashi Mitsuru Wada Yuki Fukudome Shinji Komune Shizuo |
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Affiliation: | Department of Otorhinolaryngology, Miyazaki Medical College, Kiyotake, Japan. kimituki@fc.miyazaki-med.ac.jp |
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Abstract: | Using conventional whole-cell voltage-clamp recordings, we examined the 4-aminopyridine (4-AP)- and tetraethylammonium (TEA)-sensitive K(+) currents in the cochlear inner hair cells (IHCs) of guinea pigs. 4-AP-sensitive currents were activated slowly and sustained the same current level, whereas TEA-sensitive currents were activated rapidly, followed by inactivation. The inactivation time course of TEA-sensitive currents was voltage-dependent, becoming faster at more depolarized levels. The inactivation of TEA-sensitive currents almost recovered within 5 ms. 4-AP- and TEA-sensitive K(+) currents coexisted in the same IHC. |
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