妊高征患者血清瘦素水平与外周血B细胞和T细胞亚群检测的临床意义

目的:探讨了妊高征患者血清瘦素水平与外周血B细胞和T细胞亚群水平的变化及临床意义.方法:采用放射免疫分析和单克隆抗体法对32例妊高征患者进行了血清瘦素水平和外周血B细胞及T细胞水平检测,并与35名正常妊娠妇女作比较.结果:妊高征患者血清瘦素、B细胞数均非常显著地高于正常人组(P＜0.01).血CD3、CD4/CD8则显著地低于正常人组(P＜0.01).结论:检测妊高征患者血清瘦素水平以及外周血B细胞和T细胞亚群水平的变化在一定程度上反映了机体的免疫功能状态,具有一定的临床实用价值.

Clinical Significance of Determination of Serum Leptin Level, Peripheral B Cell Number, T Cell Subset Distribution Type in Patients with Pregnancy Induced Hypertension

Objective To investigate the clinical significance of changes of serum leptin level, B cell number,T cell subsets in patients with pregnancy induced hypertension (PIH). Methods Serum leptin levels (with RIA), peripheral B cell number,T cell subsets distribution type (with monoclonal anti-body technic) were determined in 32 patients with pregnaney induced hypertension (PIH) and 35 controls. Results The serum leptin levels and B cell percentage were significantly higher in patients with PIH than those in controls (P<0.01), while the CD3, CD4 percentage and CD4/CD8 ratio were significantly lower (P<0.01). Conclusion Determination of serum leptin levels and peripheral B cell number, T cell subsets distribution type might demonstrate immuno-disturbances in patients with pregnancy induced hypertension.