口服和静脉应用呕必亭预防化疗所致胃肠道反应的疗效比较

①目的 观察比较胶囊剂和针剂呕必亭控制化疗所致胃肠道反应的效果。②方法 36例接受最初两个周期化疗的恶性肿瘤病人，采用随机自身对照的方法分别用胶囊剂或针剂两种剂型，均在化疗前30min应用单剂量（均为5mg），每天1次，且与化疗日期同步，二者均联用地塞米松10mg静脉滴注。③结果 化疗第1－5天二者控制恶心、呕吐及改善进食情况的疗效均非常满意，且有效率没有差别，其不良反应亦相似。④结论 应用胶囊剂或针剂呕必亭控制化疗所致恶心、呕吐及改善进食的疗效均很肯定，相同剂量的两种剂型控制化疗反应的效果相当。

A COMPARISON OF ORAL AND INTRAVENOUS NAVOBAN IN THE PREVENTION OF CHEMOTHERAPY-INDUCED GASTROINTESTINAL REACTIONS

Objective To compare the efficacy of preventing chemotherapy induced gastrointestinal reactions between oral and intravenous use of Navoban. Methods 36 patients with malignant tumors , who received the initial two courses of intravenous chemotherapy, were studied randomly. These patients were given oral or intravenous Navoban alternately. Navoban pills or injection, 5mg daily, was administered 30 minutes prior to chemotherapy. A combination of 10mg of dexamethasone was given intravenously to both groups. Results The efficacy of both types of administration was satisfactory in controlling nausea and vomiting as well as improving the appetite of the patients. The efficacy rate and adverse effects were similar. Conclusion The therapeutic efficacy is definite for Navoban , both pills and injection, in terms of prevention of chemotherapy induced gastrointestinal side effects and promoting appetite of the patients.