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Substance P-containing trigeminal sensory neurons project to the nucleus of the solitary tract |
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| Authors: | Elizabeth H. South Robert C. Ritter |
| Affiliation: | 1. Department of Human Anatomy and Psychobiology, School of Medicine, University of Murcia, Murcia, Spain;2. Institute of Neuroscience/CSIC, University Miguel Hernandez, San Juan de Alicante, Spain;3. Nina Ireland Laboratory of Developmental Neurobiology, Center for Neurobiology and Psychiatry, Department of Psychiatry, UCSF, San Francisco, CA, USA;1. Centre de Recherche du CHU de Québec, CHUL-Neurosciences, Québec, QC, Canada;2. Faculty of Medicine, Department of Psychiatry and Neurosciences, Université Laval, Québec, QC, Canada;1. Institute of Veterinary Physiology, University of Zurich, Zurich, Switzerland;2. Department of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, England;3. Department of Psychology, University of Illinois at Chicago, Chicago, IL, United States;4. Centre of Integrative Human Physiology, University of Zurich, Zurich, Switzerland |
| Abstract: | Intense substance P-like immunoreactivity (SPLI) was identified in fiber bundles coursing between the spinal nucleus of the trigeminal nerve and the ventrolateral nucleus of the solitary tract at the level of the area postrema. These bundles were apparent only when tissue was stained for substance P immunoreactivity and were not visible in preparations treated with antisera to somatostatin or neurotensin. Following unilateral section of the trigeminal nerve, the SPLI-containing fiber bundles were absent ipsilateral to the nerve section. The fibers were absent bilaterally in rats which were previously injected with capsaicin. Unilateral removal of the nodose ganglion did not diminish the intensity or apparent number of SPLI fibers. These data indicate the presence of a trigeminosolitary projection which is composed of primary trigeminal sensory neurons containing substance P. The results provide an anatomical route by which substance P of trigeminal origin may modulate vagal or glossopharyngeal sensory information. |
| Keywords: | substance P trigeminal sensory neuron nucleus of the solitary tract cranial nerve neuropeptide |
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