乌鲁木齐维吾尔族与汉族前列腺癌骨转移的对比分析

目的 探讨分析乌鲁木齐地区维吾尔族(以下简称维族)与汉族前列腺癌患者骨转移的特点.方法 对25例维族和41例汉族前列腺癌患者用SPECT进行全身核素骨显像,采用放射免疫法分析法检测血清骨钙素水平,采用化学发光免疫分析法检测血清游离前列腺特异抗原(F-PSA)和血清总前列腺特异抗原(T-PSA)水平及其比值(F/T).结果 骨显像阳性率维族为52.0%(13例),汉族为75.6%(31例),差异有统计学意义(P<0.05);汉族患者血清骨钙素水平明显高于维族患者(P<0.05),对于血清F-PSA和T-PSA水平,两民族间无统计学差异(P>0.05),但其比值(F/T)汉族明显低于维族 (P<0.05).结论 乌鲁木齐地区维族与汉族前列腺癌患者骨转移情况可能存在差异,应引起重视.

Comparative analysis of bone metastasis in prostate cancer of Uygur and Han people in Urumqi region

Objective To analyze the characteristics of bone metastasis in prostate cancer of Uygur and Han people in Urumqi region in Xinjiang.Methods Bone scanning with SPECT was performed in 25 Uygur patients with prostate cancer（PCa） and 41 Han patients with PCa.Serum osteocalcin was detected by radioimmunoassay.Serum total prostate-specific antigen（T-PSA）,free prostate specific antigen（F-PSA）,and the ratio（F/T） were detected by chemiluminescence immunoassay.Results The positive rate of bone scintigraphy was 52.0%（13 cases）in Uygur PCa patients and 75.6%（31cases） in Han PCa patients,and the difference was statistically significant（P0.05）.The level of serum osteocalcin in Han PCa patients was significantly higher than that in the Uygur PCa patients（P0.05）.As to the level of F-PSA and T-PSA,there was not statistically significant difference between Uygur and Han PCa patients（P0.05）.However,the ratio of F/T in Han PCa patients was significantly lower than that in the Uygur PCa patients（P0.05）.Conclusions There might be difference in bone metastasis in PCa between Uygur and Han people in Urumqi region in Xinjiang that clinicians should pay attention to.