Arterial reservoir-excess pressure and ventricular work |
| |
Authors: | Kim H Parker Jordi Alastruey Guy-Bart Stan |
| |
Institution: | (1) Department of Bioengineering, Imperial College, London, SW7 2AZ, UK;(2) Department of Biomedical Engineering, King’s College, London, SE1 7EH, UK;(3) Department of Bioengineering and Centre for Synthetic Biology and Innovation, Imperial College, London, SW7 2AZ, UK |
| |
Abstract: | This study is based on the hypothesis that the pressure within the arterial network can be usefully decomposed as the sum
of a reservoir pressure and an excess pressure. The reservoir pressure waveform is defined to be the same in each vessel but
delayed by the wave travel time from the root of the aorta. Using calculus of variations and mass conservation, which relates
the flow and rates of change of pressure in the vessels, we show that the reservoir pressure waveform minimises the ventricular
hydraulic work for any physiologically or clinically reasonable ejection waveform and arterial properties, i.e. vessel compliances
and terminal resistances. We conclude that the excess pressure determines the excess work done by the ventricle, which may
have clinically important implications. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|