| BMSC向成骨细胞分化的信号传导通路 |
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| 引用本文： | 郭常军,费琴明,张键. BMSC向成骨细胞分化的信号传导通路[J]. 国际外科学杂志, 2009, 36(5). DOI: 10.3760/cma.j.issn.1673-4203.2009.05.015 |
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| 作者姓名： | 郭常军 费琴明 张键 |
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| 作者单位： | 复旦大学附属中山医院骨科,上海,200032;复旦大学附属中山医院骨科,上海,200032;复旦大学附属中山医院骨科,上海,200032 |
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| 摘 要： | 骨髓间充质干细胞(bone mesenchymal stem cell,BMSC)是一种多潜能干细胞,具有向成骨细胞分化的能力.在BMSC向成骨细胞分化中,有膜内成骨和软骨内成骨2条途径,而且受到众多信号传导通路调控.本文结合相关文献,简要介绍BMWSmads、Runx2/osterix、Hedgehog、Wnt/β-Catenin和MAPK信号传导通路.
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| 关 键 词： | BMSC 成骨细胞 信号传导通路 |
Signal transduction pathways of BMSC differentiating to osteoblast cuo |
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| GUO Chang-Jun,FEI Qin-Ming,ZHANG Jian. Signal transduction pathways of BMSC differentiating to osteoblast cuo[J]. International Journal of Surgery, 2009, 36(5). DOI: 10.3760/cma.j.issn.1673-4203.2009.05.015 |
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| Authors: | GUO Chang-Jun FEI Qin-Ming ZHANG Jian |
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| Abstract: | Bone mesenchymal stem cell is a kind of multi-potential stem cells and can differentiate into osteoblast. The differentiation has membrane bone formation and enchondral bone formation two channels, and is regulated by numerous signal transduction pathways. According to related literatures, we review the signal transduction pathways of BMP/Smads, Runx2/osterix, Hedgehog, Wnt/β-Catenin and MAPK. |
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| Keywords: | BMSC |
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