缬沙坦和依那普利治疗原发性高血压的对比研究

目的比较缬沙坦与依那普利治疗轻中度原发性高血压的疗效及安全性。方法随机将高血压患者100例分为2组:缬沙坦组(51例),依那普利组(49例),分别观察两药治疗高血压患者4、8周的有效率。结果两组治疗第2、4、8周后显示,两药均可有效降低患者血压,整个治疗期间血压持续平稳下降。缬沙坦与依那普利治疗4、8周降低舒张压的有效率分别为88.2%、81.6%,8周有效率分别为92.2%、87.8%,两组比较,有显著性差异(P>0.05)。结论缬沙坦是一种安全、有效、耐受性好、不良反应轻的降压药。

Effects of valsartan and enalapril on patients with essential hypertension

Objective To compare the therapeutic effect and safety of valsartan with that of enalapril on patients with essential hypertension.Methods The patients were randomized to two groups:Valsartan group(n=51),Enalapril group(n=49).The effective rate was observed at 4th and 8th week.Results The blood pressure(BP) decreased significantly in both 2 groups after 2,4 and 8 weeks,and BP decreased smoothly and continuously during the entire treatment period.The effective rate for decreased DBP treatment were 88.2% and 92.2% respectively in Valsartan group after 4 and 8 weeks,and that of Enalapril group were 81.6% and 87.8% respectively.There was no significant difference between 2 groups(P>0.05).Conclusion Valsartan is a safe,effective,tolerable antihypertensive drug.