| TIL细胞对不同肿瘤细胞的细胞毒活性研究 |
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| 引用本文： | 夏圣,王胜军,邵启祥,许化溪,严俊,郑金旭,孙丽萍. TIL细胞对不同肿瘤细胞的细胞毒活性研究[J]. 江苏大学学报(医学版), 1997, 0(4) |
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| 作者姓名： | 夏圣 王胜军 邵启祥 许化溪 严俊 郑金旭 孙丽萍 |
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| 作者单位： | 上海第二医科大学 |
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| 摘 要： | B7分子是提供协同刺激信号的重要分子，包括B7－1（CD80）、B7－2（CD86），其相应配体为CD28、CTLA－4。B7－1分子与CD28结合后能诱导协同刺激信号的产生，癌性胸水来源的淋巴细胞体外用重组人IL-2（rhIL－2）激活后，对肿瘤细胞也具有较强的细胞毒性；也被认为是一类TIL。本文观察了B7分子在TIL细胞的细胞毒中的作用，发现B7－1基因转化MDA-453肿瘤细胞后，能增强TIL细胞对此转化肿瘤细胞的细胞毒活性。
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| 关 键 词： | B7-1／CD80 TIL 肿瘤 |
The Cytotoxity of TIL on B7-transducted Tumor Cell |
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| Xia shen, Wang shenjiu, Shao qixiang,et al.. The Cytotoxity of TIL on B7-transducted Tumor Cell[J]. Journal of Jiangsu University Medicine Edition, 1997, 0(4) |
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| Authors: | Xia shen Wang shenjiu Shao qixiang et al. |
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| Affiliation: | Department of microbiology-immunology |
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| Abstract: | B7 molecular t a importment co-stimulated information molecular, embraced B7-1 (CD80) andB72 (CD86). Its ligands were CD28/CTLA-4. The conjugation of B7-1 and CD28 could induce the costimulated information. The lymphocyte, derived from cancerous chest fluids and induced by IL-2,was considered aother TIL. it bad cytotoxity. The transduction of B7-1 to MDA-453 tumor cell wasable to enhance the cytotoxity of TIL. |
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| Keywords: | B7-2/CD80 TIL Tumor |
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