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| 营养不良性肺水肿大鼠肺泡液体清除机制的研究 | |
| 引用本文： | 李乃静,李伟,谷秀,李胜岐,何平. 营养不良性肺水肿大鼠肺泡液体清除机制的研究[J]. 中国比较医学杂志, 2011, 21(12). DOI: 10.3969/j.issn.1671-7856.2011.12.009 |
| 作者姓名： | 李乃静 李伟 谷秀 李胜岐 何平 |
| 作者单位： | 1. 中国医科大学附属盛京医院老年病科,辽宁,沈阳110004 2. 沈阳药科大学药物分析教研室,辽宁,沈阳 110016 3. 中国医科大学附属盛京医院呼吸科,辽宁,沈阳110004 |
| 摘 要： | 目的 探讨营养不良性肺水肿大鼠肺泡液体清除功能的变化及其机制.方法 制备营养不良性肺水肿大鼠动物模型,分别于48 h和120 h测定大鼠肺泡液体清除率(AFC)、总肺水量(TLW)和肺血管外水量(EVLW).将钠通道阻断剂氨氯吡咪、Na-K-ATP酶阻断剂哇巴因及β2受体激动剂特布他林分别灌注到正常及禁食120 h大鼠的肺泡腔内,测定AFC的变化.结果 大鼠禁食48 h AFC(19.7 ±3.22％)与正常大鼠AFC( 18.5±2.21％)比较没有明显变化；120 h时AFC(9.50±2.19％)明显降低.氨氯吡咪、哇巴因明显降低营养不良性肺水肿大鼠AFC (P ＜0.05),特布他林对营养不良性肺水肿大鼠AFC的作用与对照组大鼠比较差异无显著性(P＞0.05).结论 营养不良性肺水肿与钠通道及Na-K-ATP酶及的活性被抑制,导致肺泡液体清除能力降低有关. |
| 关 键 词： | 营养不良 肺泡液体清除率 肺水肿 肺损伤 |
Mechanisms Responsible for the Changes in Alveolar Fluid Clearance in Rats with Malnutrition |
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| LI Nai-jing,LI Wei,GU Xiu,LI Sheng-qi,HE ping. Mechanisms Responsible for the Changes in Alveolar Fluid Clearance in Rats with Malnutrition[J]. Chinese Journal of Comparative Medicine, 2011, 21(12). DOI: 10.3969/j.issn.1671-7856.2011.12.009 | |
| Authors: | LI Nai-jing LI Wei GU Xiu LI Sheng-qi HE ping |
| Affiliation: | LI Nai-jing1,LI Wei2,GU Xiu3,LI Sheng-qi3,HE ping1(1.the Third Division of Respiratory Medicine,Department of Gerontology,Shengjing Affiliated Hospital,China Medical University,Shenyang 110004,China,2.College of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016) |
| Abstract: | Objective To study the mechanisms responsible for the changes in alveolar fluid clearence in rats with malnutrition.Methods Rats were fasted but allowed access to water for 120 hours.Alveolar fluid clearance(AFC),lung water content(TLW) and extravascular lung water(EVLW) of the rats were calculated in the rats with malnutrition.Isotonic 5% album in solutions with amiloride,ouabain and terbutalin were instilled into the distal airways in the malnutrition and control rat lungs,and the AFC was examined.Results... |
| Keywords: | Malnutrition Alveolar fluid clearance Pulmonary edema Lung injury |
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