老年男性骨密度与牙周炎关系Meta分析

目的采用Meta分析方法综合分析和评价国内外发表的有关老年男性骨密度与牙周炎关系的相关文献,为有效防治老年男性骨质疏松症、牙周炎提供科学依据。方法于2011年1—4月在广州医学院第二附属医院联合检索国内外的医学文献数据库,获取国内外有关老年男性骨密度与牙周炎危险因素关系的病例对照研究资料。按标准筛选文献,然后进行文献评价和Meta分析。结果共检出相关文献137篇,其中8篇符合入选标准。8篇论著累计样本量4038人,其中牙周炎1794人。总效应测定结果显示牙周炎组与非牙周炎组老年男性骨密度差异有统计学意义(Z=3.14,P=0.002),老年男性骨密度降低者患牙周炎的风险比骨密度水平正常者高;WMD及95%CI为-0.01(上限-0.01,下限-0.02)。结论老年男性骨密度与牙周炎的发病具有相关性。

Meta-analysis of association between bone mineral density and periodontitis in old men

Objective To analyze and evaluate the literature data related to the relationship between bone mineral density and periodontitis by means of Meta-analysis and provide scientic proof for the prevention and treatment of osteoporosis and periodontitis. Methods Electronic databases about periodontics, orthopedics and endocrinology were searched for data about the association between bone mineral density and periodontitis by means of Meta-analysis.. Data were analyzed using software for preparing and maintaining Cochrane reviews and statistical analysis software. Results Totally 137 pieces of literature were selected based on the criteria, 8 of which were in accordance with the criteria, induding 4038 cases of which 1794 were periodontitis patients. The bone mineral density of older men in periodontitis patients was lower than that of the non-periodontitis patients, and it has statistical significance （Z = 3.14, P = 0.002）. Statistical significance was identified for the bone mineral density of older men （WMD ： -0.01 ; 95% CI ： -0.01, -0.02-0.01 ）. Conclusion The study shows that men bone mineral density in the old men has relationship with periodontitis.