扶正消癌汤辅助治疗食管癌术后化疗的疗效观察

目的:观察扶正消癌汤辅助治疗食管癌术后化疗的临床疗效。方法:将76例食管癌术后患者随机分为治疗组和对照组。对照组37例采用采用5-氟尿嘧啶(5-Fu)、顺铂(DDP)化疗,并作必要的对症处理。治疗组39例,在对照组的基础于术后即开始用扶正消癌汤,疗程12周,观察两组不良反应、KPS评分,并测定血清免疫球蛋白含量。结果:术后及化疗后治疗组在胃排空障碍、腹泻、食欲减退、体重减轻>5%等不良反应发生方面均低于对照组(P<0.05,P<0.01);治疗组在术后1月、化疗结束及化疗结束后2周KPS评分均高于对照组(P<0.01);治疗组治疗后IgG,IgA,IgM水平均高于对照组(P<0.05,P<0.01);治疗后治疗组有效率79.48%,对照组70.27%,两组总疗效相当。结论:扶正消癌汤能减轻食管癌手术及化疗所致不良反应,提高患者生存质量,提高机体免疫力。

Clinical Efficacy Fuzheng Xiao'ai Decoction Treatment for Esophageal Cancer after Chemotherapy

Objective:To observe the clinical efficacy of Fuzheng Xiao'ai decoction (FX) treatment for esophageal cancer after chemotherapy. Method: Seventy-six cases of esophageal cancer after surgery were randomly divided into treatment and control groups. Control group of 37 cases was treated with 5-fluorouracil (5-FU), cisplatin (DDP), and with the necessary symptomatic treatment. On the treatment basis of the control group, the treatment group (n=39) was postoperatively started FX for 12 weeks. The adverse reactions, KPS score, and serum immunoglobulin were observed. Result: The incidences of adverse reactions in treatment group were lower than those in the control group (P<0.05, P<0.01) including the delayed gastric emptying, diarrhea, loss of appetite and the weight loss> 5%. After 1 month of treatment, at the end of chemotherapy and two weeks after the end of chemotherapy, KPS score were higher in the treatment group (P<0.01). In the treatment group, IgG, IgA, and IgM levels were higher than those in the controls by the end of the treatment (P<0.05, P<0.01). However, the total effective rates in the treatment group and the control group were 79.48% and 70.27% accordingly. Conclusion: FX can reduce the adverse reactions caused by esophageal cancer surgery and chemotherapy to improve patients' quality of life, improve immune function.