| 斑马鱼模型在常见骨疾病研究中的应用 |
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| 引用本文： | 王小琦,孙岩,张洋,赵宏斌,李文辉. 斑马鱼模型在常见骨疾病研究中的应用[J]. 中国比较医学杂志, 2017, 27(6): 86-91 |
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| 作者姓名： | 王小琦 孙岩 张洋 赵宏斌 李文辉 |
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| 作者单位： | 昆明医科大学第一附属医院, 云南 昆明 650032;中国科学院昆明动物研究所, 云南 昆明 650032,昆明医科大学第一附属医院, 云南 昆明 650032;中国科学院昆明动物研究所, 云南 昆明 650032,昆明医科大学第一附属医院, 云南 昆明 650032,昆明医科大学第一附属医院, 云南 昆明 650032,中国科学院昆明动物研究所, 云南 昆明 650032 |
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| 基金项目： | 国家自然科学基金委-云南省人民政府联合基金项目（编号：U150220034）。 |
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| 摘 要： | 斑马鱼作为一种新型的脊椎模式生物,近年来在人类疾病模型中已广泛应用,特别是在人类骨疾病模型的研究中已显示出优势,如在疾病的相关基因及其功能表达和药效筛选评价等方面。这对于在骨疾病领域发挥特色疗效的传统医药而言,也具有重大的现实意义。本文就斑马鱼在骨质疏松、骨折、骨关节炎等常见骨疾病中的研究应用进行综述,以便给未来的临床相关研究提供一定的思路。
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| 关 键 词： | 斑马鱼 骨疾病 动物模型 |
| 修稿时间： | 2016-11-15 |
Application of zebrafish models in the research on bone diseases |
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| WANG Xiao-qi,SUN Yan,ZHANG Yang,ZHAO Hon-bin and LI Wen-hui. Application of zebrafish models in the research on bone diseases[J]. Chinese Journal of Comparative Medicine, 2017, 27(6): 86-91 |
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| Authors: | WANG Xiao-qi SUN Yan ZHANG Yang ZHAO Hon-bin LI Wen-hui |
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| Affiliation: | First Affiliated Hospital, Kunming Medical University, Kunming 650032, China;Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650032,First Affiliated Hospital, Kunming Medical University, Kunming 650032, China;Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650032,First Affiliated Hospital, Kunming Medical University, Kunming 650032, China,First Affiliated Hospital, Kunming Medical University, Kunming 650032, China and Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650032 |
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| Abstract: | Zebrafish (Danio rerio), as a new vertebrate model organism, has been widely used in human disease research in recent years, especially in the study of human bone diseases. The zebrafish models show some advantages, such as expression of disease-related genes and application in pharmacodynamic screening and evaluation, etc. It is also of great practical significance for the traditional medicine, which has a characteristic efficacy in the treatment of bone diseases. This paper reviews the research and application of zebrafish in research on bone diseases such as osteoporosis, fracture, osteoarthritis, and so on, aiming to provide some inspiration for the future clinically relevant research. |
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| Keywords: | Zebrafish Bone diseases Animal models |
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