右心衰竭动物模型的建立和比较

右心衰竭(RVF)是一种严重危害人类生命健康的临床综合征。RVF动物模型的建立与应用,是研究RVF发病机制、病理生理学和防治方案的关键环节。近年来,众多学者对RVF模型的建立方法、检测指标等方面进行了深入研究,使得造模成功率、模型质量得到很大提高。虽然RVF动物模型较多,但由于造模方法不一,选材及处理条件不同,目前尚无公认的实验模型。本文将对已报道的RVF动物模型的建立方法、造模原理进行归纳整理和比较评价,为今后在RVF研究中的选择和应用提供参考。

Establishment and comparison of right ventricular failure of animal models

Right ventricular failure(RVF)is a severe clinical syndrome that affects human health seriously.The establishment and application of experimental animal models are critical to research the pathogenesis, pathophysiology, prevention and treatment of RVF. Recently, numerous researchers have studied the modeling methods and testing indexes of RVF of animal models, which has improved the success rate and quality of the models. However, even if so many models, there is still no widely accepted experimental animal model of RVF because of the different and complex modeling methods, material selection and experimental conditions. This article reviews the methods and mechanism of multiple experimental animal models of RVF and compares them, so as to provide reference for choosing and applying experimental animal models of RVF in the study.