| HPLC法测定酮洛芬缓释胶囊中主药的含量 |
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| 引用本文： | 杨青,李明. HPLC法测定酮洛芬缓释胶囊中主药的含量[J]. 中国药房, 2007, 18(25): 1980-1981 |
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| 作者姓名： | 杨青 李明 |
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| 作者单位： | 山东泰安市药品检验所,泰安市,271000 |
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| 摘 要： | 目的:建立以高效液相色谱法测定酮洛芬缓释胶囊中主药含量的方法。方法:色谱柱为C18,流动相为0.05mol·L-1磷酸二氢钾溶液-甲醇(60∶40),流速为1.0mL·min-1,检测波长为255nm,进样量为20μL。结果:酮洛芬检测浓度的线性范围为10.84～54.20μg·mL-1(r=0.9995);平均回收率为99.91%,精密度为0.26%。结论:本方法操作简便、快速、准确、专属性强,可用于该制剂的含量测定。
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| 关 键 词： | 酮洛芬 缓释胶囊 高效液相色谱法 含量测定 |
| 文章编号： | 1001-0408（2007）25-1980-02 |
| 收稿时间： | 2006-10-08 |
| 修稿时间： | 2007-02-06 |
Determination of the Content of Ketoprofen in Ketoprofen Sustained Release Capsules by HPLC |
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| YANG Qing,LI Ming. Determination of the Content of Ketoprofen in Ketoprofen Sustained Release Capsules by HPLC[J]. China Pharmacy, 2007, 18(25): 1980-1981 |
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| Authors: | YANG Qing LI Ming |
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| Abstract: | OBJECTIVE: To establish a HPLC method for the determination of ketoprofen in ketoprofen sustained release capsules. METHODS: The determination was performed on C18 column. The mobile phase consisted of 0. 05mol· L- 1 KDP solution- methanol ( 60∶ 40) with a flow rate of 1. 0mL· min- 1. The detection wavelength was set at 255 nm and the sample size was 20μ L. RESULTS: The linear range of ketoprofen was 10. 84～ 54. 20μ g· mL- 1 ( r=0. 999 5) with average recovery at 99. 91% and precision at 0. 26% . CONCLUSION: The determination method is simple, rapid, accurate and specific, and it can be used for the content determination of ketoprofen in ketoprofen sustained release capsules. |
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| Keywords: | Ketoprofen Sustained release capsules HPLC Content determination |
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