| ＂Anti-HBc alone＂ in human immunodeficiency virus-positive and immuno-suppressed lymphoma patients |
| |
| 作者姓名： | Yu Xuan Koo Daniel SW Tan Iain BH Tan Richard Quek Miriam Tao Soon Thye Lim |
| |
| 作者单位： | Yu Xuan Koo(Yong Loo Lin School of Medicine,National University of Singapore,10 Medical Drive,Singapore 117597,Singapore);Daniel SW Tan,Iain BH Tan,Richard Quek,Miriam Tao,Soon Thye Lim(Department of Medical Oncology,National Cancer Centre Singapore,11 Hospital Drive,Singapore 169610,Singapore) |
| |
| 摘 要： | Hepatitis B virus （HBV） infection is endemic in various parts of the world. A proportion of patients have resolved prior exposure to HBV, as evidenced by the clearance of circulating hepatitis B surface antigen and the appearance of antibody to hepatitis B core antigen （anti-HBc）, which could produce protective antibody to hepatitis B surface antigen （anti-HBs）. With time, anti-HBs in some patients may become negative. Such patients are described as having occult HBV infection or ＂anti-HBc alone＂. In the context of immunodeficient patients, such as HIV patients or lymphoma patients undergoing immunosuppressive immunotherapy, the lack of protective anti-HBs may increase the risk of hepatitis B reactivation. Serum HBV DNA testing may be necessary in ＂anti-HBc alone＂ patients, to detect patients at a high risk of developing HBV infection allowing appropriate prophylactic management.
|
| 关 键 词： | 人类免疫缺陷病毒 免疫反应 HBc 淋巴瘤 患者 阳性 乙型肝炎表面抗原 乙型肝炎病毒 |
| 收稿时间： | 2009 May 20 |
"Anti-HBc alone" in human immunodeficiency virus-positive and immuno-suppressed lymphoma patients |
| |
| Yu Xuan Koo,Daniel SW Tan,Iain BH Tan,Richard Quek,Miriam Tao,Soon Thye Lim."Anti-HBc alone" in human immunodeficiency virus-positive and immuno-suppressed lymphoma patients[J].World Journal of Gastroenterology,2009,15(30):3834-3835. |
| |
| Authors: | Yu Xuan Koo Daniel SW Tan Iain BH Tan Richard Quek Miriam Tao Soon Thye Lim |
| |
| Institution: | 1. Yong Loo Lin School of Medicine,National University of Singapore,10 Medical Drive,Singapore 117597,Singapore
2. Department of Medical Oncology,National Cancer Centre Singapore,11 Hospital Drive,Singapore 169610,Singapore |
| |
| Abstract: | Hepatitis B virus (HBV) infection is endemic in various parts of the world. A proportion of patients have resolved prior exposure to HBV, as evidenced by the clearance of circulating hepatitis B surface antigen and the appearance of antibody to hepatitis B core antigen (anti-HBc), which could produce protective antibody to hepatitis B surface antigen (anti-HBs). With time, anti-HBs in some patients may become negative. Such patients are described as having occult HBV infection or "anti-HBc alone". In the context of immunodeficient patients, such as HIV patients or lymphoma patients undergoing immunosuppressive immunotherapy, the lack of protective anti-HBs may increase the risk of hepatitis B reactivation. Serum HBV DNA testing may be necessary in "anti-HBc alone" patients, to detect patients at a high risk of developing HBV infection allowing appropriate prophylactic management. |
| |
| Keywords: | Hepatitis B virus Human immunodeficiency virus Antibody to hepatitis B core antigen Hepatitis B virus DNA Viral hepatitis |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
