Nephrotic syndrome in a mother and her infant: relationship with cytomegalovirus infection |
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Authors: | Marisa Giani Alberto Edefonti Beatrice Damiani Giuseppina Marra Daniela Colombo Giovanni Banfi Emilio Rivolta Erich H. Strøm Michael Mihatsch |
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Affiliation: | (1) Department of Pediatrics II, University of Milan, Milan, Italy;(2) Nephrology Division, Ospedale Maggiore, Milan, Italy;(3) Institute of Pathology, University of Basel, Switzerland;(4) Pediatric Dialysis Unit, Clinica Pediatrica G. e D. De Marchi, Via Commenda, 9, I-20122 Milan, Italy |
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Abstract: | This case report describes infantile nephrotic syndrome (NS) in a baby girl with a clinically severe cytomegalovirus (CMV) infection. Culture of the baby's urine was positive for CMV and IgM anti-CMV antibodies were detected. After an unsuccessful course of corticosteroids, gancyclovir treatment was started and a remission of cutaneous, pulmonary, and renal symptoms was achieved. As the mother also developed NS at the end of pregnancy, a common etiology could be postulated, although there were no signs of recent CMV infection in the mother, only anti-CMV IgG. The relationship between CMV infection and glomerular disease is still unclear: NS may represent another manifestation of CMV disease. |
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Keywords: | Infantile nephrotic syndrome Cytomegalovirus infection Pregnancy |
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