呼吸系统疾病患者血清PTPr 含量分析

 目的　研究呼吸系统疾病患者血清PTPr 含量及其意义。方法　用EL ISA 法测患者血清PT-Pr ,然后分组统计分析。结果　48 例肺癌PTPr 含量(36. 4 ±27. 8 ) ng/ ml ,阳性( > 30ng/ ml ) 32 例(66. 7 %) ,十分显著高于以下各组( P < 0. 001) ;肺结核病48 例PTPr 含量(7. 9 ±14. 1) ng/ ml ,阳性4 例(8. 3 %) ;肺炎56 例PTPr 含量(11. 6 ±16. 6) ng/ ml ,阳性4 例(7. 1 %) ;其他疾病54 例PTPr 含量(8. 1±15. 6) ng/ ml ,阳性4 例(7. 4 %) 。结论　肺癌患者血清PTPr 含量显著增高。提示肺癌发生发展中信号传导分子活化增强;测定PTPr 对肺癌诊断可能具有临床价值。

Quantification of O-Phospho-L-tyrosine Protein(PTPr) in the Sera of Respiratory Patients

Objective 　The quantities of serum Phospho-L-tyrosine protein ( PTPr) in groups of respiratory patient s and it s value were studied. Methods 　An EL ISA was applied to detect serum PTPr of the groups of patient s , and then the result s of each group were statistically analyzed and compared. Results 　The serum PTPr in lung cancer group was (36. 4 ±27. 8) ng/ ml ; 36 (66. 7 %) in the 48 cases were positive (PTPr > 30ng/ ml) ; and the both were significantly higher than those in the following groups ( P <0. 001) . The PTPr amount s and positives in pneumo2tuberculosis , pneumonia and other respiratory diseases groups were respectively (7. 9 ±14. 1) ng/ ml and 8. 3 %(4/ 48) , (11. 6 ±16. 6) ng/ ml and 7. 1 %(4/56) , and (8. 1 ±15. 6) ng/ ml and 7. 4 %(4/ 54) . Conclusion 　In lung cancer patient s the serum PTPrwere increased evidently ; it suggested that the activation of signaling molecules be enhanced in lung cancer cell generation and growth , and assaying PTPr may be of value in lung cancer diagnosis.