Facilitation of opiate-and enkephalin-induced motor activity in the mouse by phenytoin sodium and carbamazepine |
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Authors: | R J Katz Kristine Schmaltz |
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Institution: | (1) Mental Health Research Institute, Department of Psychiatry, University of Michigan Medical Center, 48109 Ann Arbor, MI, USA |
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Abstract: | In the first experiment, adult male Swiss-Webster mice were systemically injected with a standard dose of morphine. Compared to the influence of vehicle, the motor activity of morphine-injected mice was increased. Neither phenytoin sodium nor carbamazepine alone facilitated motor activity, but pretreatment with both drugs further facilitated the increased motor activity produced by morphine. In a second experiment, mice were injected centrally with a long-acting analog of leu-enkephalin. It also increased motor activity in comparison with vehicle. Again, both phenytoin sodium and carbamazepine further facilitated this response. Both experiments suggest a facilitatory interaction between some aspects of these anticonvulsants and opiate-induced motor activity. |
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Keywords: | Anticonvulsant drugs Carbamazepine Enkephalin Morphine Motor Opiate Phenytoin sodium Psychomotor activity |
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