Buspirone increases locus coeruleus noradrenergic neuronal activity in vitro |
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Authors: | M E Trulson L J Henderson |
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Affiliation: | Department of Pharmacology, Marshall University School of Medicine, Huntington, WV 25701, U.S.A. |
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Abstract: | Buspirone, a non-benzodiazepine anxiolytic agent, produced dose-dependent increases in the activity of norepinephrine-containing locus coeruleus neurons recorded from mouse brain slices in vitro. The response was not changed in a low calcium/high magnesium incubation medium, indicating that the observed effects were the result of a direct action of buspirone on locus coeruleus neurons. These data suggest that noradrenergic neurons may not be as important in mediating anxiety states as previously suggested. |
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Keywords: | Buspirone Norepinephrine Locus coeruleus In vitro Single units Anxiety |
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