| cAMP依赖性蛋白激酶在血管平滑肌细胞增殖周期中的变化 |
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| 引用本文： | 张明志 张光毅. cAMP依赖性蛋白激酶在血管平滑肌细胞增殖周期中的变化[J]. 徐州医学院学报, 1990, 10(2): 84-88 |
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| 作者姓名： | 张明志 张光毅 |
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| 作者单位： | 徐州医学院生物化学研究室(张明志，张光毅，赵文君，纵艳艳)，徐州医学院生物化学研究室(赵昇皓) |
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| 摘 要： |
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| 关 键 词： | cAMP 蛋白激酶 平滑肌 细胞增殖 |
VARIATION OF cAMP-DEPENDENT PROTEIN KINASE IN PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS |
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| Zhang Mingzhi. VARIATION OF cAMP-DEPENDENT PROTEIN KINASE IN PROLIFERATION OF VASCULAR SMOOTH MUSCLE CELLS[J]. Acta Academiae Medicinae Xuzhou, 1990, 10(2): 84-88 |
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| Authors: | Zhang Mingzhi |
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| Abstract: | Variation of cAMP-dependent protein kinase (PK-A) activities in cell cycle of cultured rabbit aortic smooth muscle cells (ASMC) was studied. In cell cytosol, with the entry of Go cells into cell cycle, there was a decrease in PK-A activity with a trough at 6hr and an increase in late G1 with a peak at 9hr. In nuclear, with the entry of Go cells into cell cycle, also there was a decrease in PK-A activity as in cytosol with the lowest point at 3hr. and an increase in late G1 with a peak at 9hr. These results suggest that PK-A may play a positive effect on the proliferation of ASMC. |
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| Keywords: | cAMP-dependent protein kinase proliferation smooth muscle cells rabbit. |
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