| 硫酸头孢喹肟的合成 |
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| 引用本文： | 邵意阳,屈一新,任慧. 硫酸头孢喹肟的合成[J]. 中国医药工业杂志, 2007, 38(6): 405-406 |
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| 作者姓名： | 邵意阳 屈一新 任慧 |
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| 作者单位： | 北京化工大学化学工程学院,北京,100029 |
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| 摘 要： | 头孢噻肟用六甲基二硅胺烷保护氨基和羧基后与三甲基碘硅烷进行取代反应,与5,6,7,8-四氢喹啉进行3-位取代后用甲醇处理得到头孢喹肟氢碘酸盐,阴离子交换树脂除去碘离子后与硫酸成盐,得抗生素硫酸头孢喹肟-水合物,总收率约48%.
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| 关 键 词： | 头孢喹肟 头孢噻肟 抗生素 合成 |
| 文章编号： | 1001-8255（2007）06-0405-02 |
| 修稿时间： | 2007-02-22 |
Synthesis of Cefquinome Sulfate |
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| SHAO Yi-yang,Qu Yi-xin,REN hui. Synthesis of Cefquinome Sulfate[J]. , 2007, 38(6): 405-406 |
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| Authors: | SHAO Yi-yang Qu Yi-xin REN hui |
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| Affiliation: | College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029 |
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| Abstract: | The amido group and carboxyl group of cefotaxime were protected by reacting with hexamethyl disilazane, then underwent 3-substistution by trimethyliodosilane and 5,6,7,8-tetrahydroquinoline successively, and treated with methanol to obtain cefquinome hydroiodide, which after ion exchange to remove the iodide and neutralized with sulfuric acid to give cefquinome sulfate in 48 % overall yield. |
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| Keywords: | cefquinome cefotaxime antibacterial synthesis |
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