乙型肝炎血清腺苷酸脱氨酶与肝纤维化血清标志物测定的临床意义

目的：探讨乙型肝炎患者血清腺苷酸脱氨酶（ADA）、透明质酸（HA）、层黏蛋白（LN）、Ⅳ型胶原（C—IV）及Ⅲ型前胶原（PCⅢ）检测的临床意义。方法：选择选择2011年8月至2012年12月海南省人民医院收治的30例乙型肝炎患者作为观察组，同期38例健康体检者作为正常对照组．分别检测两组血清ADA活性，HA、LN、C-IV、PCⅢ水平。结果：观察组患者血清ADA活性、HA、LN、C—IV、PCm水平明显高于正常对照组（P〈0．01）。结论：乙型肝炎患者血清ADA的活性与HA、LN、C—IV、PCⅢ水平的变化可反映肝脏损伤程度和肝纤维化趋势．对早期诊断治疗及预后判断有重要的临床价值。

Clinical significance of measurement of serum adenosine deaminase and liver fibrotic biomarkers in hepatitis B

Objective：To investigate the clinical significance of measurement of serum adenosine deaminase （ADA） , hyaluronic acid （HA） , laminin （LN） , type IV collagen （C-IV） and type m procollagen （ PC HI ） in hepatitis B. Methods： We assayed the ADA activity and the levels of HA, LN, C-1V and PCII1 in 30 patients with hepatitis B who were admitted to Hainan People＇s Hospital between August 2011 and December 2012 （ observation group） and 38 volunteers scheduled for health check-up （control group）. Results： The observation group was associated with markedly increased ADA activity and higher levels of HA, LN, C-1V and PCIll （all P 〈0.01 ）. Conclusion： Changes in the ADA activity and the levels of HA, LN, C-IV and PCIll may sensitively reflect the degree of liver injury and fibrosis and should be considered worthwhile for promoting early diagnosis and treatment and r, redictin~ the prognosis of hetatitis B.