T cell antigen-receptor signal transduction. |
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| Authors: | J E van Leeuwen L E Samelson |
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| Affiliation: | National Cancer Institute, Building 37, Room 1E24, Laboratory of Cellular and Molecular Biology, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. vanleeuj@box-v.nih.gov |
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| Abstract: | During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-Cgamma1-Ca2+ signalling pathways. TCR-induced cytoskeletal changes involve signalling through SLP-76-Vav-Nck to activate effectors of the Rho-family of GTPases. Finally, glycolipid-enriched microdomains play a crucial role in T cell activation. |
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