深圳市某区学龄前儿童丙型肝炎血清流行病学调查

目的:C型肝炎目前并未有疫苗预防接种,因此对C型肝炎的流行情况、尤其是C型肝炎病毒的致病机转及感染途径方面的探讨,以其切断感染源,是为迫切需要。方法:以多步骤抽样法在区、街道中心与郊乡地区筛检54所幼儿园。从静脉采血取得血清,以自动化仪器测试肝功能指针研究数据,以SPSS软件系统做统计分析。结果:有19位儿童为C型肝炎抗体阳性,占2.3%。男孩的C型肝炎抗体流行率比女孩高,但经统计学处理无显著差异(ORm:1.6;95%CI:0.9～2.8;P=0.08)。3～4岁年龄段的流行率比5～6岁低(ORm:2.2;95%CI:1.1～4.2;P=0.02)。经多变项调整分析后,具C型肝炎抗体流行率的儿童且受B型肝炎病毒自然感染的比未被感染的高,但经统计学处理无显著差异(ORm:2.6;95%CI:0.9～7.4;P=0.08 for HBV-infected vs.uninfected)。结论:在龙岗区,C型肝炎病毒的感染与B型肝炎病毒自然的感染,除了性别与居住地外,应该还有更多的共同传染途径存在。另外,为数不少的居民相信药物注射比口服治疗快,尤其是对儿童的治疗,因此间接造成C型肝炎病毒感染的数量增加。

Studies on seroepidemiology of hepatitis C viruses infection among preschool children in Longgang

Objective:Investigating the epidemic of hepatitis C,especially the pathogenesis and the transmission routes of hepatitis C virus infection,in order to cut off the source of infection,it is an urgent need because there is no hepatitis C vaccination Methods:A community-based survey was carried out in 54 kindergartens in urban areas,rural areas and aboriginal areas randomly selected through stratified sampling.Liver function indicators were tested by automated equipment,statistical analysis was done by SPSS software system.Results:A total of 19 children were anti-HCV seropositive,giving a prevalence of 2.3%.Boys had a higher anti-HCV seroprevalence,but not statistically significantly different from girls(ORm:1.6;95% CI:0.9-2.8;P=0.08).The seroprevalence of the age group of 3-4 years was lower than that of the age group of 5-6 years(ORm:2.2;95% CI:1.1-4.2;P=0.02).After multivariate adjustment,preschool children with natural HBV infection had a higher anti-HCV seroprevalence,but not statistically significantly different from those without natural HBV infection(ORm:2.6;95% CI:0.9-7.4;P=0.08 for HBV-infected vs.uninfected).Conclusion:HCV infection varies with gender,residential area,and natural HBV infection.HCV and HBV might share common transmission routes in Longgang.In addition,a large number of residents believe that drug injection play a role in treatment faster than oral therapy,especially for the treatment of children,so increase the number of hepatitis C virus infection indirectly.