In vivo studies on evaluation of potential toxicity of unspent tannins using albino rats (Rattus norvegicus) |
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Authors: | Munuswamy Sudha A. Gnanamani G. Deepa M. Sudha E. Madhavacharyulu K. Deivanai S. Sadulla |
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Affiliation: | aMicrobiology Division, Central Leather Research Institute, Adyar, Chennai 20, Tamil Nadu, India |
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Abstract: | The present study emphasizes the effect of unspent tannins on liver, kidney and heart of albino rats. Oral administration of unspent tannins at three different concentrations was made for a period of seven days. Carbon tetrachloride served as positive control. Tissues were removed carefully followed by sacrifice and were subjected to sectioning and H&E staining. Histopathological examination of the sections showed, major tissue damage with the highest concentration of tannins (1500 mg/kg body weight) irrespective of their nature and source, followed by moderate damage with the 1000 mg/kg bw and zero damage with 500 mg/kg bw. However, complete damage was observed with the tissues of positive control group. Lipid peroxidase assay using post-mitochondrial supernatant of liver, kidney and heart showed appreciable levels of malondialdehyde release at higher concentrations of tannins. |
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Keywords: | Antioxidant Unspent tannins Lipid peroxidation Histopathology Tissue damage |
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