甘肃栽培麻黄镇咳、平喘、抗炎、利尿作用研究

目的研究甘肃栽培麻黄的镇咳、平喘、抗炎、利尿作用,并与野生麻黄比较。方法采用氨水诱咳法、气管容积法、耳廓肿胀法及代谢笼法,测定各药理作用指标。结果2种麻黄均可减少小鼠咳嗽反应的次数,对抗气管平滑肌痉挛性收缩,减轻小鼠耳廓肿胀度,增加大鼠尿量。结论甘肃栽培麻黄在镇咳、平喘、抗炎、利尿作用方面与野生麻黄作用相当,可替代野生麻黄药用。

Antitussive, Antiasthmatic, Antiinflammatory and Diuretic Effects of Herba Ephedrae Cultivated Artificially in Gansu Province

OBJECTIVE: To study the antitussive, antiasthmtic, anti-inflammatory and diuretic effects of Herba Ephedrae cultivated artificially in Gansu province and to compare which with the wild Herba Ephedrae. METHODS: Each pharmacological action index was determined by concentrated ammonia method, windpipe capacity method, pinna swelling method and metabolic cage method. RESULTS: Both of the two kinds of Herba Ephedrae could reduce the cough responses of mice, resist the spasmodic contraction of the tracheal smooth muscles, reduce the swelling of auricle of mice and increase urine volume of rats. CONCLUSIONS: Herba Ephedrae cultivated artificially in Gansu province are equivalent to the wild one in terms of the antitussive, antiasthmtic, anti-inflammatory and diuretic effects thus it can serve as a substitute for the wild one.