| 重症肌无力患者末梢血Th1和Th2细胞内细胞因子的变化及意义 |
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| 引用本文： | 梅风君,韩颖,刘青蕊,段宏伟.重症肌无力患者末梢血Th1和Th2细胞内细胞因子的变化及意义[J].脑与神经疾病杂志,2009,17(3):228-230. |
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| 作者姓名： | 梅风君 韩颖 刘青蕊 段宏伟 |
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| 作者单位： | 河北医科大学第四医院神经内科,石家庄,050011 |
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| 摘 要： | 目的研究重症肌无力(MG)患者末梢血细胞因子及抗乙酰胆碱受体抗体(AchRab)水平,探讨细胞因子在MG发病中的作用。方法研究对象为17例MG患者,分为急性期组10例,非急性期组7例,设健康对照组15例。应用流式细胞术(FCM)测定末梢血产生各型细胞因子(CK)的CD4+T细胞%,采用酶联免疫吸附法(ELISA)测定血清中抗乙酰胆碱受体抗体(AchRab)。结果⑴MG患者急性期组和非急性期组IFN-γ+IL-4-CD4+T细胞%及AchRab的含量比健康对照组显著增多(P<0.05和P<0.001);⑵急性期组和非急性期组IFN-γ-IL-4+和IL-13+CD4+T细胞%比健康对照组显著减少(P<0.05);⑶IL-10+CD4+T细胞%各组之间无显著性差异;⑷各组IFN-γ+IL-4-CD4+T细胞%与AchRab均呈正相关。结论MG患者Th1和Th2细胞因子的平衡紊乱,Th1细胞因子IFN-γ对MG患者自身抗体的产生有促进作用。
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| 关 键 词： | 重症肌无力 细胞因子 乙酰胆碱受体抗体 |
The study of Th1 and Th2 cytokines in myasthenia gravis patients |
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| MEI Feng-jun,HAN Ying,LIU Qing-rui,DUAN Hong-wei.The study of Th1 and Th2 cytokines in myasthenia gravis patients[J].Journal of Brain and Nervous Diseases,2009,17(3):228-230. |
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| Authors: | MEI Feng-jun HAN Ying LIU Qing-rui DUAN Hong-wei |
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| Institution: | MEI Feng-jun,HAN Ying,LIU Qing-rui,DUAN Hong-wei. Department of Neurology,The Forth Hospital of Hebei Medical University,Shijiazhuang 050011,China |
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| Abstract: | Objective To investigate the role of various intracellular cytokines in the pathogenesis of myasthenia gravis (MG), the level of cytokines and AchRab in the peripheral blood were measured. Methods In this study the patient group included 10 acute cases and 7 non-acute cases; the control group induded 15 healthy people. CD4+ T cells with different cytokines were measured by flow cytometry (FCM). Enzyme-linked immunosorbent assay (ELISA) was used to measure the concentration of AchRab. Results (1) the percent... |
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| Keywords: | myasthenia gravis cytokine AchRab |
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