| 非甾体抗炎药研究的最新进展 |
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| 引用本文： | 戴海霞,张晓燕,徐开俊,陈建华.非甾体抗炎药研究的最新进展[J].药物生物技术,2012(1):90-94. |
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| 作者姓名： | 戴海霞 张晓燕 徐开俊 陈建华 |
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| 作者单位： | 中国药科大学物理化学教研室;日照市人民医院眼科;中国药科大学分子生物学教研室 |
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| 摘 要： | 非甾体抗炎药(NSAIDs)是一类广泛用于抗炎、解热、镇痛的药物,但由于胃肠道毒副作用和肾毒性使它的应用受到很大限制。因此研制出能降低传统NSAIDs副作用且具良好活性的新型NSAIDs成为这类药物发展的主要方向,如选择性环氧化酶-2(COX-2)抑制剂、一氧化氮释放型NSAIDs、环氧化酶/脂氧合酶(COX/LOX)双重抑制剂、脂蛋白磷脂酶A2(LP-PLA2)抑制剂、前列腺素E2合成酶-1(mPGES-1)抑制剂以及肿瘤坏死因子-α(TNF-α)抑制剂等。本文从这几个方面对NSAIDs最新研究进行了简要介绍。
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| 关 键 词： | 非甾体抗炎药 脂蛋白磷脂酶A2 前列腺素E2合成酶-1 肿瘤坏死因子-α |
Recent Research Advances of Nonsteroidal Anti-Inflammatory Drugs(NSAIDs) |
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| DAI Hai-xia,ZHANG Xiao-yan,XU Kai-jun,CHEN Jian-hua.Recent Research Advances of Nonsteroidal Anti-Inflammatory Drugs(NSAIDs)[J].Pharmaceutical Biotechnology,2012(1):90-94. |
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| Authors: | DAI Hai-xia ZHANG Xiao-yan XU Kai-jun CHEN Jian-hua |
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| Institution: | 1.Department of Physical Chemistry,China Pharmaceutical University,Nanjing 210009,China;2.Department of Ophthalmology,Rizhao People’s hospital,Rizhao 276826,China;3.Department of Molecular Biology,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Nonsteroidal anti-inflammatory drugs(NSAIDs) are a class of widely prescribed drugs for the use of anti-inflammatory,antipyretic and analgesic,but their application have been restricted for their gastrointestinal side effects and renal toxicity.Therefore,to develop novel NSAIDs with lower side effects and excellent activity,compared with the traditional NSAIDs,becomes the main direction of these drugs development.Emerging trends are represented by selective cyclooxygenase-2(COX-2) inhibitors,nitric oxide-release NSAIDs,dual COX/lipoxygenase(LOX) inhibitors,lipoprotein phospholipase A2(LP-PLA2) inhibitor,prostaglandin E2 synthase-1(mPGES-1) inhibitors,tumor necrosis factor-α(TNF-α) inhibitors and so on.In this paper,the latest research on NSAIDs has been briefly introduced from these several aspects. |
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| Keywords: | NSAIDs Lp-PLA2 mPGES-1 TNF-α |
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