静滴单硝酸异山梨酯及硝酸甘油治疗慢性充血性心力衰竭的临床观察

目的:比较静脉滴注单硝酸异山梨酯(ISMN)及硝酸甘油(NTG)治疗慢性充血性心力衰竭(CHF)的临床疗效及不良反应。方法:115例心功能Ⅲ～Ⅳ级的CHF患者随机分为两组,分别用ISMN(58例)和NTG(57例)静脉滴注,治疗15天后,比较两组疗效及不良反应发生的情况。结果:ISMN治疗15天后CHF患者心功能改善的显效率和总有效率均明显高于NTG组(P<0.01);左室射血分数(LVEF)、左室短轴缩短率(FS)、快速充盈期及心房收缩二尖瓣血流速度(E/A)均显著高于NTG组(P<0.01);治疗后血压(Bp)及血尿素氮(BUN)均有下降;ISMN组不良反应轻微,患者耐受性好。结论:静脉滴注ISMN治疗CHF患者疗效好、不良反应轻微,可作为治疗CHF患者的有效措施之一。

Clinical study of isosorbide mononitrate and nitroglycerin in the treatment of chronic congestive heart failure

Objective:To compare the clinical effects and side reactions of isosorbide mononitrate(ISMN) and nitroglycerin(NTG) in the treatment of chronic congestive heart failure(CHF).Methods:115 patients with CHF were divided into two groups,ISMN group(n=58),NTG group(n=57).Two groups were treated with ISMN or NTG respectively once a day.The clinical effects and side reactions of two groups were compaed after 15 days.Results:The rate of showing efficacy and total effective rate of heart function of patients with CHF in ISMN group were obviously higher than those in NTG group(P<0.01).The LVEF?FS and E/A of patients with CHF in ISMN group were obviously higher than those in NTG group(P<0.01).Blood preasure(BP)and BUN of the patients with CHF in two groups lowed after treatment.Conclusion:The clinical effect of ISMN is better than that of NTG.And the side effects of ISMN are milder than those of NTG.