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Autophagy in Huntington disease and huntingtin in autophagy
Affiliation:1. Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada;2. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA;3. Research Center on Aging, Department of Physiology and Biophysics, University of Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada;4. Genzyme, a Sanofi Company, Framingham, MA 01701, USA;5. Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, 138648, Singapore;6. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 138648, Singapore;1. Department of Pediatrics, University of California, San Diego, La Jolla, CA 92037, USA;2. Department of Cellular & Molecular Medicine, University of California, San Diego, La Jolla, CA 92037, USA;3. Department of Neurosciences, University of California, San Diego, La Jolla, CA 92037, USA;4. Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92037, USA;5. Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92037, USA;6. Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA;7. Rady Children''s Hospital, San Diego, CA 92193, USA;1. REQUIMTE/LAQV, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal;2. Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
Abstract:
Keywords:autophagy  Huntington disease  myristoylation  neurodegeneration  post-translational modifications  trafficking  therapies  caspases
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