SLC16A11、SLC16A13基因多态性与乙型肝炎相关性肝癌的关联性分析

目的 探讨SLC16A11和SLC16A13基因与乙型肝炎相关性肝癌的关联性。方法 选取于河北医科大学附属第一医院、第二医院、第四医院和河北省石家庄市第五医院的住院患者和体检人群1 039例。其中乙型肝炎相关性肝癌患者421例，为病例组；健康者370例和HBV自然清除者248例，分别为对照组。采用χ²检验、二分类Logistic回归等统计分析方法，对SLC16A11、SLC16A13基因多态性与乙型肝炎相关性肝癌的关联性进行分析并计算比值比。结果 以HBV自然清除人群为对照，与AA基因型相比，携带SLC16A13 rs4796576位点AG基因型可以显著增加患癌风险(OR=1.544,95%CI:1.073～2.224);与C等位基因相比，在显性模型中，携带G等位基因同样显著增加患癌的风险(OR=1.530,95%CI:1.079～2.170)。结论 以HBV自然清除人群为对照，SLC16A13 rs4796576基因多态性与乙型肝炎相关性肝癌的罹患有关。

Association analysis of SLC16A11, SLC16A13 gene polymorphism and hepatitis B-related liver cancer

ObjectiveTo investigate the association between SLC16A11 and SLC16A13 genes and hepatitis B-related liver cancer.MethodsIn total, 1 039 inpatients and physical examinees were selected from the First Hospital of Hebei Medical University, the Second Hospital of Hebei Medical University, the Fourth Hospital of Hebei Medical University and the Fifth Hospital of Shijiazhuang City, Hebei Province. Among them, 421 patients with hepatitis B-related liver cancer were selected as case group, and 370 healthy people and 248 with natural clearance of HBV as the control group. The association between SLC16A11, SLC16A13 gene polymorphisms and hepatitis B-related liver cancer was analyzed and the odds ratio was calculated by using statistical analysis methods such as χ2 test and binary logistic regression analysis.ResultsThe population with natural clearance of HBV served as controls. When compared with AA genotype, the AG genotype of the SLC16A13 rs4796576 gene could significantly increase the risk of cancer (OR=1.544, 95%CI：1.073-2.224). Compared with the C allele, the dominant model carrying the G allele of the SLC16A13 rs4796576 gene also significantly increased the risk of cancer (OR=1.530, 95%CI：1.079-2.170).ConclusionCompared with the population with naturally clearance of HBV, the SLC16A13 rs4796576 gene polymorphisms is related to hepatitis B-related liver cancer.