胰腺神经内分泌肿瘤患者腹腔镜术后住院时间延长的危险因素分析

目的 探究胰腺神经内分泌肿瘤（pNETs）患者行腹腔镜手术后住院时间延长的危险因素。方法 回顾性分析2015年1月至2022年8月在浙江省人民医院行腹腔镜手术治疗的91例pNETs患者的临床资料。以术后住院时间是否超过中位住院时间12 d将患者分为住院时间正常组（NLOS组，≤12 d,n=50）和住院时间延长组（PLOS组，>12 d,n=41）。通过单因素和多因素Logistic回归分析患者术后住院时间延长的危险因素，用AUC和Brier分数评价区分度和校准度。结果 单因素及多因素分析显示，手术时间>210 min(OR=8.850,95%CI 2.699～29.013,P<0.001)和腹腔镜手术方式腹腔镜胰十二指肠切除术（LPD）:OR=5.753,95%CI 1.062～31.155,P=0.042；腹腔镜胰腺体尾切除术（LDP:OR=8.547,95%CI1.908～38.291,P=0.005]是患者住院时间延长的独立危险因素。此时相应的AUC为0.785,Brier分数为0.182。结论 手术时间和手术方式是预测pNETs患者腹腔镜术后住院时间是否延...

Risk factors of prolonged length of hospital stay after laparoscopic surgery for patients with pancreatic neuroendocrine tumors

Objective To investigate the risk factors of prolonged length of hospital stay (PLOS) after laparoscopic surgery for patients with pancreatic neuroendocrine tumors (pNETs). Methods The clinical data of 91 patients with pNETs in Zhejiang Provincial People’s Hospital between Jan. 2015 and Aug. 2022 were retrospectively analyzed. With 50% of the length of hospital stay (LOS) as the cut-off point, patients were divided into normal length of hospital stay (NLOS) group (LOS≤12 d, n=50) and PLOS group (LOS > 12 d,n=41). Univariate and multivariate Logistic regression analyses were used to explore the risk factors of PLOS after laparoscopic surgery for patients with pNETs. Results Univariate and multivariate Logistic regression analyses showed that, operation time > 210 min (OR=8.850, 95%CI 2.699-29.013, P<0.001), and laparoscopic operation methods laparoscopic pancreatoduodenectomy (LPD): OR=5.753, 95%CI 1.062-31.155, P=0.042; laparoscopic distal pancreatectomy (LDP): OR=8.547, 95%CI 1.908-38.291, P=0.005] were significant risk factors for PLOS, the corresponding AUC was 0.785, Brier score was 0.182. Conclusion This study shows that operation time and operation methods for pNETs are main risk factors of PLOS after laparoscopic surgery in patients with pNETs.