| 血清反应因子与肿瘤关系的研究进展 |
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| 引用本文： | 郑阿秀1,袁建玲1,罗泊涛1,揭伟1,' target='_blank'>2. 血清反应因子与肿瘤关系的研究进展[J]. 现代肿瘤医学, 2023, 0(13): 2552-2557. DOI: 10.3969/j.issn.1672-4992.2023.13.035 |
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| 作者姓名： | 郑阿秀1 袁建玲1 罗泊涛1 揭伟1 ' target='_blank'>2 |
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| 作者单位： | 1.广东医科大学第一附属医院病理诊断与研究中心,广东 湛江 524023;2.海南医学院第一附属医院肿瘤内科,海南 海口 570102 |
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| 基金项目： | 广东省“扬帆计划”高层次人才项目（编号:4YF16007G） |
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| 摘 要： | 血清反应因子(serum response factor,SRF)的异常表达与癌症密切相关,SRF的高表达增强了癌细胞的存活、增殖、迁移和侵袭能力。此外,SRF与肿瘤干细胞的生存、自我更新和肿瘤耐药有关。SRF具有致癌基因特性,一些针对SRF的特异性抑制剂备受关注。本文综述了SRF在肿瘤发生发展中的研究进展及其在癌症中的作用机制,并展望了SRF作为靶点在肿瘤防治中的意义。
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| 关 键 词： | 血清反应因子 肿瘤发病学 肿瘤靶向治疗 |
Research progress of the relationship between serum response factor and tumor |
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| ZHENG Axiu,YUAN Jianling,LUO Botao,JIE Wei,' target='_blank'>. Research progress of the relationship between serum response factor and tumor[J]. Journal of Modern Oncology, 2023, 0(13): 2552-2557. DOI: 10.3969/j.issn.1672-4992.2023.13.035 |
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| Authors: | ZHENG Axiu YUAN Jianling LUO Botao JIE Wei ' target='_blank'> |
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| Affiliation: | 1.Pathological Diagnosis and Research Center,the First Affiliated Hospital of Guangdong Medical University,Guangdong Zhanjiang 524023,China;2.Department of Oncology,the First Affiliated Hospital of Hainan Medical University,Hainan Haikou 570102,China. |
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| Abstract: | There is tight relationship between cancers and abnormal expression of SRF,and high expression of SRF strongly enhances the ability of cancer cell survival,proliferation,migration and invasion.In addition,SRF was reported to be related to cancer stem cell,self-renewal and tumor drug resistance.SRF has oncogene properties,and some specific inhibitors targeted on SRF have been attracted much attentions.This article summarizes the research progress of SRF in tumorigenesis and progression,as well as its mechanism in cancer,and we also prospect the significance of SRF as a target in tumor prevention and treatment. |
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| Keywords: | serum response factor tumor pathogenesis tumor targeted therapy |
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