肝硬化患者骨髓造血系统异常的机制研究进展及其骨髓细胞学检查的临床意义

肝硬化是由于各种原因造成慢性肝损伤后导致肝脏结构改变的一个病理过程。在疾病发展过程中可有造血系统的异常:出现外周血细胞的减少、骨髓造血细胞形态异常，以及造血干细胞和造血调控因子水平的改变。了解肝硬化骨髓造血系统异常机制和骨髓细胞学检查的临床价值对于肝硬化辅助诊断、治疗、预后及研究都具有重要意义，但目前临床上对肝硬化患者进行骨髓细胞学检查的开展度不高，因此该研究对肝硬化骨髓造血系统异常的机制及其骨髓及外周血细胞学特点作一综述，以期提高临床医生对肝硬化患者骨髓细胞学检查的重视，进一步提高肝硬化患者的诊疗水平。

Research Progress on the Mechanism of Bone Marrow Hematopoietic System Abnormalities in Patients with Liver Cirrhosis and Its Clinical Significance of Bone Marrow Cytology

Cirrhosis is a pathological process that leads to changes in liver structure after chronic liver damage due to various reasons. In the course of its disease development, there may be abnormalities in the hematopoietic system, a decrease in peripheral blood cells, abnormal morphology of bone marrow hematopoietic cells, and changes in hematopoietic stem cells and hematopoietic regulators. Understanding the abnormal mechanism of the bone marrow hematopoietic system of cirrhosis and the clinical value of bone marrow cytology are of great significance for the auxiliary diagnosis, treatment, prognosis and research of cirrhosis, and the current clinical implementation of bone marrow cytology in patients with cirrhosis is not high, so reviews the mechanism of abnormal bone marrow hematopoietic system of cirrhosis and its myeloid cytology.