运用Logistic回归联合ROC曲线评估mi R19b-3-p对抑郁症疗效的预测价值

目的 运用Logistic回归联合ROC曲线评估微小核糖核酸-19b-3p(microRNA-19b-3p, miR-19b-3p)对抑郁症疗效的预测价值。方法 选取本院收治的抑郁症患者112例为研究对象(病例组),另选取同期来本院进行体检的健康志愿者60例(作为对照组)。采用实时荧光定量聚合酶链式反应(polymerase chain reaction, PCR)法检测所有受试者外周血清miR-19b-3p表达水平，并比较治疗前2组血清miR-19b-3p表达水平及病例组治疗前后血清miR-19b-3p表达水平变化。根据治疗效果将病例组分为预后良好组和预后不良组，比较预后良好组与预后不良组血清miR-19b-3p表达水平及其他因素。采用Logistic回归分析法明确影响抑郁症患者预后不良的危险因素，并绘制受试者工作特征(receiver operating characteristical, ROC)曲线分析治疗前后血清miR-19b-3p表达水平对抑郁症患者预后不良的预测价值。结果 治疗前，病例组血清miR-19b-3p水平高于对照组(P<0.05),治疗后，病例组血清miR...

The predictive value of miR-19b-3 pevaluated by Logistic regression combined with ROC curvein the treatment of depression

ObjectiveTo explore the predictive value of microRNA-19b-3p (miR-19b-3p)evaluated by Logistic regression combined with ROC curve in the treatment of depression.MethodsA total of 112 patients with depression admitted to our hospital were selected as the research subjects (case group), and 60 healthy volunteers who presented to our hospital for physical examination during the same period were selected as the control group. The expression levels of peripheral serum miR-19b-3p in all subjects were detected by real-time quantitative polymerase chain reaction (PCR), and the expression levels of serum miR-19b-3p in the two groups before treatment and changes in the expression levels of serum miR-19b-3p in the case group before and after treatment were compared. According to the therapeutic effect, the case group was subdivided into a good prognosis group and a poor prognosis group, and the serum miR-19b-3p expression levels and other factors were compared between the good prognosis group and the poor prognosis group. Logistic regression analysis was used to identify the risk factors for poor prognosis in patients with depression, and receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of serum miR-19b-3p expression levels before and after treatment for poor prognosis in patients with depression.ResultsBefore treatment, the serum miR-19b-3p level in the case group was higher than that in the control group (P＜0.05), and after treatment, the serum miR-19b-3p level in the case group was lower than that before treatment (P＜0.05). Family history of depression (positive), poor treatment compliance, poor family social support, poor relationship with neighbors, the proportion of major life events, the number of episodes, and serum miR-19b-3p levels before and after treatment were higher in the poor prognosis group than in the good prognosis group (P＜0.05). Logistic regression analysis showed that poor treatment compliance, poor family social support, associated psychotic symptoms, miR-19b-3p (before and after treatment), and major life events were all risk factors for poor prognosis in patients with depression (P＜0.05). ROC curve analysis showed that the area under the ROCcurve (AUC), sensitivity, specificity and the optimal cut-off point of serum mir-19b-3p level before treatment in predicting the poor prognosis of patients with depression were 0.739, 78.56%, 64.28%, and 11.25, respectively. The AUC, sensitivity, specificity, and optimal cut-off point of serum miR-19b-3p levels after treatment in predicting poor prognosis in patients with depression were 0.756, 80.75%, 60.15%, and 7.14, respectively.ConclusionSerum miR-19b-3p is abnormally highly expressed in patients with depression, which has a certain relationship with the poor prognosis of patients with depression, and can be used to predict the prognosis of patients with depression.