lncRNA OVAAL、miR-335、TRIM 14在子宫内膜癌中表达及与临床特征相关性研究

目的 探讨卵巢腺癌扩增长非编码RNA(long non-coding RNA,lncRNA OVAAL)、微小RNA(microRNA,miR)-335、三重基序蛋白14(tripartite motif 14,TRIM 14)在子宫内膜癌(endometrial cancer, EC)中表达及与临床特征相关性。方法 选取我院EC患者86例作为癌组织组，同期子宫内膜息肉(endometrial polyps, EP)患者86例作为EP组织组。检测EC癌组织、癌旁组织及EP组织lncRNA OVAAL、miR-335、TRIM14表达，分析其与EC临床特征间关系及对EC复发风险的预测价值。结果 癌组织组lncRNA OVAAL、TRIM14表达高于癌旁组织组、EP组织组，miR-335表达低于癌旁组织组、EP组织组(P<0.05),EP组织组lncRNA OVAAL、TRIM14表达高于癌旁组织组，miR-335表达低于癌旁组织组(P<0.05);癌组织lncRNA OVAAL、miR-335、TRIM14表达与FIGO分期、组织学分级、肌层浸润深度、淋巴结转移、血管侵犯、病...

Expression of lncRNA OVAAL,miR-335 and TRIM 14 in endometrial cancer and its correlation with clinical characteristics

ObjectiveTo investigate the expression of ovarian adenocarcinoma amplified long non-coding RNA(lncRNA OVAAL), microRNA(miR)-335 and tripartite motif 14(TRIM14) in endometrial carcinoma(EC) and their correlation with clinical characteristics.MethodsA total of 86 EC patients in our hospital were selected as the case group, and 86 patients with endometrial polyps(EP) during the same period were selected as the control group. The expressions of lncRNA OVAAL, miR-335 and TRIM14 in EC cancer tissues, adjacent tissues and endometrial polyps were detected. Their relationship with clinical characteristics of EC and their predictive value for the risk of EC recurrence were analyzed.ResultsThe expression of lncRNA OVAAL and TRIM14 in cancer tissue was higher than that in adjacent tissue and EP tissue, while the expression of miR-335 was lower than that in adjacent tissue and EP tissue(P＜0.05). The expression of lncRNA OVAAL and TRIM14 in EP tissues was higher than that in adjacent tissue, and the expression of miR-335 was lower than that in adjacent tissue(P＜0.05). The expression of lncRNA OVAAL, miR-335 and TRIM14 in cancer tissue was related to FIGO stage, histological grade, depth of myometrial invasion, lymph node metastasis, vascular invasion, and pathological type(P＜0.05). The expression of lncRNA OVAAL and TRIM14 in cancer tissues of patients with recurrence was higher than that of patients without recurrence, and the expression of miR-335 was lower than that of patients without recurrence(P＜0.05). After adjusting for FIGO stage, histological grade, depth of myometrial invasion, lymph node metastasis, vascular invasion, and extent of lymph node dissection, the expression of lncRNA OVAAL, miR-335 and TRIM14 were the influencing factors of EC recurrence(P＜0.05). The AUC of lncRNA OVAAL, miR-335 and TRIM14 combined to predict EC recurrence was greater than that of single index.ConclusionThe abnormal expression of lncRNA OVAAL, miR-335 and TRIM14 in cancer tissue is related to FIGO stage, histological grade, depth of myometrial invasion, lymph node metastasis, vascular invasion, and pathological type in EC patients, which can be used as important indicators for predicting postoperative recurrence.