甲状腺激素水平与糖尿病肾病患者高尿酸血症发生的相关性

目的 分析甲状腺激素水平与糖尿病肾病（diabetic kidney disease，DKD）患者发生高尿酸血症（hyperuricemia，HUA）的关系。 方法 选取医院收治的DKD患者102例，根据患者是否发生HUA分为发生组（50例）与未发生组（52例）。分析2组一般资料和实验室指标，采用Pearson双变量相关性和Logistic回归分析甲状腺激素水平与DKD患者HUA发生的关系。 结果 DKD患者102例中，发生HUA 50例，发生率为49.02%；发生组的血尿酸、三酰甘油（triglyceride，TG）、促甲状腺激素（thyroid stimulating hormone，TSH）水平均高于未发生组，游离三碘甲腺原氨酸（free triiodothyronine，FT3）和游离甲状腺素（free thyroxine，FT4）水平均低于未发生组（P＜0.05）；组间其他一般资料、实验室指标等相关情况比较差异无统计学意义（P＞0.05）；采用Pearson双变量相关性分析结果显示，DKD患者血尿酸水平与血脂、TSH水平呈正相关（P＜0.05）；DKD患者血尿酸水平与FT3、FT4水平呈负相关（P＜0.05）；经Logistic回归分析结果显示，TSH、FT3、FT4水平与DKD患者发生HUA有关（P＜0.05）。 结论 甲状腺激素水平与DKD患者的HUA发生有关。

Correlation between thyroid hormone level and hyperuricemia in patients with diabetic nephropathy

Objective To analyze the relationship between thyroid hormone level and hyperuricemia (HUA) in patients with diabetic nephropathy (DKD).Methods A total of 102 patients with DKD treated in the hospital were selected. Patients were divided into occurrence group (n=50) and non-occurrence group (n=52) according to presence of HUA. The baseline data and laboratory indexes of the two groups were analyzed. Pearson bivariate correlation and Logistic regression were used to analyze the relationship between thyroid hormone level and HUA in patients with DKD.Results Among 102 patients with DKD, 50 patients developed HUA, with an incidence rate of 49.02%. The levels of serum uric acid, triacylglycerol (TG) and thyroid stimulating hormone (TSH) in the occurrence group were higher than those in the non-occurrence group, while the levels of free triiodothyronine (FT3) and free thyroxine (FT4) were lower than those in the non-occurrence group (P＜0.05). There was no significant difference in other baseline data and laboratory indexes between groups (P＞0.05). Pearson bivariate correlation analysis was used, and the results showed that the level of serum uric acid was positively correlated with the levels of blood lipid and TSH in patients with DKD (P＜0.05), while the level of serum uric acid was negatively correlated with the levels of FT3 and FT4 in patients with DKD (P＜0.05). Logistic regression analysis showed that the levels of TSH, FT3 and FT4 were related to the occurrence of HUA in patients with DKD (P＜0.05).Conclusion Thyroid hormone levels are associated with HUA in patients with DKD.