甲状旁腺激素1型受体在肾脏疾病中的研究进展

甲状旁腺激素1型受体（PTH1R）是G蛋白偶联受体家族成员之一，在体内广泛表达，参与体内胚胎发育、钙磷稳态、机体代谢、肿瘤发生等多种过程。PTH1R在肾脏中高度表达，PTH1R的活化可涉及多种复杂机制，参与肾脏疾病的发生、发展，与多种肾脏疾病如糖尿病肾病、肾小球肾炎、急性肾损伤、慢性肾脏病等关系密切。本文就PTH1R功能及其在肾脏疾病中发挥的作用和机制进行综述，深入探讨PTH1R与肾脏疾病的关系和相关机制，以期为肾脏疾病的诊断和治疗提供新思路。

Recent Developments in Parathyroid Hormone Type 1 Receptor and Kidney Disease

Parathyroid hormone type 1 receptor (PTH1R), a member of the G-protein-coupled receptor family, is extensively expressed in the human body and is involved in various processes such as embryonic development, calcium and phosphorus homeostasis, body metabolism and tumorigenesis. PTH1R is highly expressed in the kidney, and its activation is involved in the development and progression of renal diseases though multiple mechanisms and complicated pathways, and is closely associated with a variety of renal diseases such as diabetic nephropathy, glomerulonephritis, acute kidney injury, and chronic kidney disease. This article reviews recent studies about the function of PTH1R, and its role and mechanism of action in renal diseases, and provides an in-depth discussion on the relationship and related mechanisms between PTH1R and kidney diseases, offering new ideas for the diagnosis and treatment of kidney diseases.